P
Patrick A. Baeuerle
Researcher at Amgen
Publications - 314
Citations - 59914
Patrick A. Baeuerle is an academic researcher from Amgen. The author has contributed to research in topics: T cell & Antigen. The author has an hindex of 115, co-authored 305 publications receiving 57875 citations. Previous affiliations of Patrick A. Baeuerle include University of Freiburg & Ludwig Maximilian University of Munich.
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Patent
Nuclear factors associated with transcriptional regulation
David Baltimore,Ranjan Sen,Phillip A. Sharp,Harinder Singh,Louis M. Staudt,Jonathan H. LeBowitz,Albert S. Baldwin,Roger G. Clerc,Lynn M. Corcoran,Patrick A. Baeuerle,Michael J. Lenardo,Chen-Ming Fan,Thomas P. Maniatis +12 more
TL;DR: In this paper, constitutive and tissue-specific protein factors which bind to transcriptional regulatory elements of Ig genes (promoter and enhancer) are identified and isolated by an improved assay for protein-DNA binding.
Journal ArticleDOI
T lymphocytes can be effectively recruited for ex vivo and in vivo lysis of AML blasts by a novel CD33/CD3-bispecific BiTE antibody construct.
Michael Aigner,J Feulner,Stefanie Schaffer,Roman Kischel,Peter Kufer,K Schneider,Anja Henn,Benno Rattel,Matthias Friedrich,Patrick A. Baeuerle,Andreas Mackensen,Stefan W. Krause +11 more
TL;DR: Ex vivo experiments in immunodeficient mice demonstrated significant inhibition of tumor growth by AMG330 and an inducible infiltration of human T-cells into subcutaneous HL60 tumors and the activities of the CD33/CD3-bispecific BiTE Ab construct AMG 330 warrant further development for the treatment of AML.
Journal ArticleDOI
Regression of Human Prostate Cancer Xenografts in Mice by AMG 212/BAY2010112, a Novel PSMA/CD3-Bispecific BiTE Antibody Cross-Reactive with Non-Human Primate Antigens
Matthias Friedrich,Tobias Raum,Ralf Lutterbuese,Markus Voelkel,Petra Deegen,Doris Rau,Roman Kischel,Patrick Hoffmann,Christian Brandl,Joachim Schuhmacher,Peter Mueller,Ricarda Finnern,Melanie Fuergut,Dieter Zopf,Jerry W. Slootstra,Patrick A. Baeuerle,Benno Rattel,Peter Kufer +17 more
TL;DR: AMG 212/BAY2010112 appears as a promising new BiTE antibody for the treatment of patients with PSMA-expressing PCa by induced target cell-dependent activation and cytokine release of T cells, and efficiently redirected T cells for lysis of target cells.
Journal Article
Reactive oxygen intermediates as second messengers of a general pathogen response.
TL;DR: It is proposed that these pandemic pathogens have been conserved throughout evolution as universal pathogen messengers turning on genes with important functions in the immune response and cell proliferation, thereby ensuring growth in a prooxidant environment.
Journal ArticleDOI
T-cell activation and B-cell depletion in chimpanzees treated with a bispecific anti-CD19/anti-CD3 single-chain antibody construct
Bernd Schlereth,Cornelia Quadt,Torsten Dreier,Peter Kufer,Grit Lorenczewski,Nadja Prang,Christian Brandl,Sandra Lippold,K E Cobb,Kathleen M. Brasky,Eugen Leo,Ralf C. Bargou,Krishna K. Murthy,Patrick A. Baeuerle +13 more
TL;DR: The data show that bscCD19xCD3 can be safely administered to chimpanzees at dose levels that cause fully reversible T-cell activation and, despite a very short exposure time, cumulative loss of peripheral B lymphocytes.