Patrick A. Baeuerle

TL;DR: The effect of chlorate on protein sulfation in intact cells was investigated and chlorate treatment provides a powerful tool for studying the biological significance ofprotein sulfation.

TL;DR: It is reported that nanomolar concentrations of gliotoxin inhibited the activation of transcription factor NF-kappaB in response to a variety of stimuli in T and B cells, raising the possibility that the immunosuppression observed during aspergillosis results in part from gliot toxin-mediated NF- kappaB inhibition.

TL;DR: In this phase I study of relapsed/refractory NHL, continuous infusion with CD19-targeted immunotherapy blinatumomab at various doses and schedules was feasible, with an MTD of 60 μg/m(2)/day that showed antilymphoma activity.

TL;DR: A comparative analysis of known NF-kappa B-binding sites and competition experiments with synthetic polynucleotides and oligonucleotide encompassing only one half-site or single-stranded kappa B motifs suggested that the two DNA-binding monomers in the NF-Kappa B protein complex can interact differentially with the half-sites of the decameric cognate motif.

TL;DR: In this article, the authors explored the in vitro efficacy, T-cell donor variability, binding characteristics, specificity, kinetics and interleukin-2 (IL-2) dependence of bispecific antibody (bscCD19xCD3) against human B lymphoma cell lines.