R
Ranjan Sen
Researcher at Laboratory of Molecular Biology
Publications - 128
Citations - 12112
Ranjan Sen is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Enhancer & Gene. The author has an hindex of 42, co-authored 114 publications receiving 11359 citations. Previous affiliations of Ranjan Sen include Harvard University & Brandeis University.
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Journal ArticleDOI
Multiple nuclear factors interact with the immunoglobulin enhancer sequences.
Ranjan Sen,David Baltimore +1 more
TL;DR: In this paper, an electrophoretic mobility shift assay with end-labeled DNA fragments was used to characterize proteins that bind to the immunoglobulin (Ig) heavy chain and the kappa light chain enhancers.
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Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism
Ranjan Sen,David Baltimore +1 more
TL;DR: Phorbol-ester-mediated induction of NF-kappa B was observed in a T cell line and a nonlymphoid cell line, and is therefore not restricted to B-lymphoids cells, indicating that factors that control transcription of specific genes in specific cells may be activated by posttranslational modification of precursor factors present more widely.
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Architectural Protein Subclasses Shape 3D Organization of Genomes during Lineage Commitment
Jennifer E. Phillips-Cremins,Michael E.G. Sauria,Amartya Sanyal,Tatiana I. Gerasimova,Bryan R. Lajoie,Joshua S.K. Bell,Chin-Tong Ong,Tracy A. Hookway,Changying Guo,Yuhua Sun,Michael Bland,William Wagstaff,Stephen Dalton,Todd C. McDevitt,Ranjan Sen,Job Dekker,James Taylor,Victor G. Corces +17 more
TL;DR: It is concluded that cell-type-specific chromatin organization occurs at the submegabase scale and that architectural proteins shape the genome in hierarchical length scales.
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A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes.
TL;DR: It is reported here the identification of a human B-cell nuclear factor (IgNF-A) that binds to DNA sequences in the upstream regions of both the mouse heavy and κ light-chain gene promoters and also to the mouseHeavychain gene enhancer.
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A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes.
TL;DR: Two species of nuclear proteins which bind specifically to an octamer sequence, ATTTGCAT, are detected using an electrophoretic mobility shift assay to identify DNA binding proteins.