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Harinder Singh

Researcher at University of Pittsburgh

Publications -  161
Citations -  30257

Harinder Singh is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Transcription factor & Cellular differentiation. The author has an hindex of 66, co-authored 161 publications receiving 26344 citations. Previous affiliations of Harinder Singh include Loyola University Chicago & Temple University.

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Journal ArticleDOI

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

Sven Heinz, +10 more
- 28 May 2010 - 
TL;DR: It is demonstrated in macrophages and B cells that collaborative interactions of the common factor PU.1 with small sets of macrophage- or B cell lineage-determining transcription factors establish cell-specific binding sites that are associated with the majority of promoter-distal H3K4me1-marked genomic regions.
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Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages

Edward W. Scott, +3 more
- 09 Sep 1994 - 
TL;DR: The developmental programs of lymphoid and myeloid lineages require a common genetic function likely acting at the level of a multipotential progenitor, and mice carrying a mutation in the PU.1 locus were generated by gene targeting.
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A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes.

Harinder Singh, +3 more
- 01 Jan 1986 - 
TL;DR: It is reported here the identification of a human B-cell nuclear factor (IgNF-A) that binds to DNA sequences in the upstream regions of both the mouse heavy and κ light-chain gene promoters and also to the mouseHeavychain gene enhancer.
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Transcriptional repression mediated by repositioning of genes to the nuclear lamina

Karen L. Reddy, +6 more
- 13 Mar 2008 - 
TL;DR: Three-dimensional DNA-immunoFISH is devised for inducible tethering of genes to the inner nuclear membrane (INM) and targeted adenine methylation is used to show that, as is the case for the model system, inactive immunoglobulin loci at the nuclear periphery are contacted by INM and lamina proteins.
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Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development.

Steven T. Kosak, +6 more
- 05 Apr 2002 - 
TL;DR: It is suggested that subnuclear positioning represents a novel means of regulating transcription and recombination of IgH and Igκ loci during lymphocyte development.