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Patrick Garidel

Researcher at Boehringer Ingelheim

Publications -  128
Citations -  3638

Patrick Garidel is an academic researcher from Boehringer Ingelheim. The author has contributed to research in topics: Polysorbate & Polysorbate 20. The author has an hindex of 29, co-authored 128 publications receiving 2960 citations. Previous affiliations of Patrick Garidel include Martin Luther University of Halle-Wittenberg & MorphoSys.

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Journal ArticleDOI

Strategies for the Assessment of Protein Aggregates in Pharmaceutical Biotech Product Development

John den Engelsman, +8 more
- 01 Apr 2011 - 
TL;DR: The current state of methods for analysis of protein aggregates is reviewed and why these methods should be used during product development and recommendations to the biotech community with regard to strategies for their application during the development of protein therapeutics are made.
Journal ArticleDOI

Single Particle Characterization of Iron-induced Pore-forming α-Synuclein Oligomers *

Marcus Kostka, +14 more
- 18 Apr 2008 - 
TL;DR: The results may provide a potential disease mechanism regarding the role of ferric iron and of toxic oligomer species in Parkinson diseases and allow high throughput screening for aggregation inhibitors and may provide new approaches for drug development and therapy.

Single Particle Characterization of Iron-induced Pore-forming

Marcus Kostka, +13 more
TL;DR: In this paper, the authors used confocal single-molecule fluorescence encetechniques, such as scanning for intensely fluorescent targets (SIFT) and atomicforce microscopy, to monitor people with Parkinson disease.
Journal ArticleDOI

Stabilization of IgG1 in spray-dried powders for inhalation.

S. Schüle, +4 more
- 01 Aug 2008 - 
TL;DR: Protein stabilization was improved by the addition of glycine but trehalose and sucrose were most effective in preventing aggregation, which can be primarily attributed to the water replacement properties of the sugars.
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Systematic investigation of the effect of lyophilizate collapse on pharmaceutically relevant proteins I: stability after freeze-drying.

K. Schersch, +5 more
- 01 May 2010 - 
TL;DR: The objective of this work was to investigate the effect of cake collapse during freeze-drying on the stability of protein lyophilizates containing a monoclonal IgG(1)-antibody or a second pharmaceutically relevant protein, referred to as PA01.