P
Patrick Mehlen
Researcher at University of Lyon
Publications - 179
Citations - 23121
Patrick Mehlen is an academic researcher from University of Lyon. The author has contributed to research in topics: Dependence receptor & Receptor. The author has an hindex of 62, co-authored 169 publications receiving 19075 citations. Previous affiliations of Patrick Mehlen include Claude Bernard University Lyon 1 & Sanford-Burnham Institute for Medical Research.
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Journal ArticleDOI
Netrin-1 acts as a survival factor for aggressive neuroblastoma
Céline Delloye-Bourgeois,Julien Fitamant,Andrea Paradisi,David Cappellen,Sétha Douc-Rasy,Marie-Anne Raquin,Dwayne G. Stupack,Akira Nakagawara,Raphael Rousseau,Valérie Combaret,Alain Puisieux,Dominique Valteau-Couanet,Jean Bénard,Agnès Bernet,Patrick Mehlen +14 more
TL;DR: It is proposed that interference with the netrin-1 autocrine loop in malignant neuroblasts could represent an alternative therapeutic strategy, as disruption of this loop triggers in vitro NB cell death and inhibits NB metastasis in avian and mouse models.
Journal ArticleDOI
The serum‐induced phosphorylation of mammalian hsp27 correlates with changes in its intracellular localization and levels of oligomerization
TL;DR: The oligomeric small heat-shock protein hsp27, also denoted hsp28, is constitutively expressed in several mammalian cells and displays a phosphorylation status that is related to cellular growth and differentiation.
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The dependence receptor hypothesis.
TL;DR: The current knowledge concerning dependence receptors is reviewed, including the shared mechanisms for cell death induction and their potential relevance in nervous system development and regulation of tumorigenesis.
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Anaplastic lymphoma kinase is a dependence receptor whose proapoptotic functions are activated by caspase cleavage.
Jaouhar Mourali,Alan Bénard,Filipe Calheiros Lourenço,Céline Monnet,Catherine Greenland,Christel Moog-Lutz,Claire Racaud-Sultan,Daniel Gonzalez-Dunia,Marc Vigny,Patrick Mehlen,Georges Delsol,Michèle Allouche +11 more
TL;DR: It is shown that Jurkat cells overexpressing the wild-type ALK receptor are more sensitive to doxorubicin-induced apoptosis than parental cells, and the ALK protein is cleaved during apoptosis in a caspase-dependent manner, placing it in the growing family of dependence receptors.
Journal ArticleDOI
Tumor necrosis factor-alpha induces changes in the phosphorylation, cellular localization, and oligomerization of human hsp27, a stress protein that confers cellular resistance to this cytokine.
Patrick Mehlen,Anne Mehlen,Dominique Guillet,Xavier Préville,André-Patrick Arrigo,André-Patrick Arrigo +5 more
TL;DR: It is reported that the TNF‐α‐mediated hsp27 phosphorylation is a long‐lasting phenomenon that correlates with the cytostatic effect of this cytokine and may be related to the protective activity of this protein against the deleterious effects induced by T NF‐α.