P
Patrick Rat
Researcher at French Institute of Health and Medical Research
Publications - 73
Citations - 4120
Patrick Rat is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Hyperthermic intraperitoneal chemotherapy & Cancer. The author has an hindex of 24, co-authored 70 publications receiving 3423 citations. Previous affiliations of Patrick Rat include University of Burgundy & University of Rouen.
Papers
More filters
Journal ArticleDOI
Cytoreductive Surgery Combined With Perioperative Intraperitoneal Chemotherapy for the Management of Peritoneal Carcinomatosis From Colorectal Cancer: A Multi-Institutional Study
Olivier Glehen,F. Kwiatkowski,Paul H. Sugarbaker,Dominique Elias,Edward A. Levine,M. De Simone,R. Barone,Yutaka Yonemura,Francesco Cavaliere,François Quenet,M. Gutman,A.A.K. Tentes,Gérard Lorimier,J.L. Bernard,J.M. Bereder,J. Porcheron,A. Gomez-Portilla,Perry Shen,Marcello Deraco,Patrick Rat +19 more
TL;DR: The therapeutic approach combining cytoreductive surgery with perioperative intraperitoneal chemotherapy achieved long-term survival in a selected group of patients with PC from colorectal origin with acceptable morbidity and mortality.
Journal ArticleDOI
Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy versus cytoreductive surgery alone for colorectal peritoneal metastases (PRODIGE 7): a multicentre, randomised, open-label, phase 3 trial.
François Quenet,Dominique Elias,Lise Roca,Diane Goéré,Laurent Ghouti,Marc Pocard,Olivier Facy,Catherine Arvieux,Gérard Lorimier,Denis Pezet,Frédéric Marchal,Valeria Loi,Pierre Meeus,Beata Juzyna,Hélène de Forges,Jacques Paineau,Olivier Glehen,Pascale Mariani,Cécile Brigand,J.M. Bereder,Simon Msika,Guillaume Portier,Patrick Rat +22 more
TL;DR: In this paper, the authors evaluated the specific benefit of adding hyperthermic intraperitoneal chemotherapy (HIPEC) to cytoreductive surgery compared with receiving cytoreduction surgery alone.
Journal ArticleDOI
Mutations in the RAS-MAPK, PI(3)K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers
Ludovic Barault,Nicolas Veyrie,Nicolas Veyrie,Valérie Jooste,Valérie Jooste,Delphine Lecorre,Delphine Lecorre,Caroline Chapusot,Jean Marc Ferraz,Jean Marc Ferraz,Astrid Lièvre,Astrid Lièvre,Marion Cortet,Marion Cortet,Anne Marie Bouvier,Patrick Rat,Patrick Roignot,Jean Faivre,Pierre Laurent-Puig,Pierre Laurent-Puig,F. Piard +20 more
TL;DR: This study is the first report to underline the potential role of RAS‐MAPK, PI (3)K network mutations on survival in colon cancers and the evaluation of its mutations could have clinical implications.
Journal ArticleDOI
Hypermethylator Phenotype in Sporadic Colon Cancer: Study on a Population-Based Series of 582 Cases
Ludovic Barault,Céline Charon-Barra,Valérie Jooste,Mathilde Funes de la Vega,Laurent Martin,Patrick Roignot,Patrick Rat,Anne Marie Bouvier,Pierre Laurent-Puig,Jean Faivre,Caroline Chapusot,F. Piard +11 more
TL;DR: Methylation is an independent prognostic factor in MSS colon cancer and shows the interest of defining three subgroups of patients according to their methylation status (No-CIMP/CIMp-Low/CimP-High).
Journal ArticleDOI
C-Reactive Protein Is an Early Predictor of Septic Complications After Elective Colorectal Surgery
Pablo Ortega-Deballon,François Radais,Olivier Facy,Philippe d’Athis,David Masson,Pierre E. Charles,Nicolas Cheynel,Jean-Pierre Favre,Patrick Rat +8 more
TL;DR: C-reactive protein is a simple way to ensure a safe discharge from hospital after elective colorectal surgery, and patients with CRP values >125 mg/l on the fourth postoperative day should be discharged.