P
Patrick Ruben Heisterkamp
Researcher at Dresden University of Technology
Publications - 1
Citations - 84
Patrick Ruben Heisterkamp is an academic researcher from Dresden University of Technology. The author has contributed to research in topics: Autophagy & Neurodegeneration. The author has an hindex of 1, co-authored 1 publications receiving 57 citations.
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FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy.
Lara Marrone,Hannes C.A. Drexler,Jie Wang,Priyanka Tripathi,Tania Distler,Patrick Ruben Heisterkamp,Eric N. Anderson,Sukhleen Kour,Anastasia Moraiti,Shovamayee Maharana,Rajat Bhatnagar,T. Grant Belgard,Vadreenath Tripathy,Norman Kalmbach,Zohreh Hosseinzadeh,Valeria Crippa,Masin Abo-Rady,Florian Wegner,Angelo Poletti,Dirk Troost,Eleonora Aronica,Volker Busskamp,Joachim Weis,Udai Bhan Pandey,Anthony A. Hyman,Simon Alberti,Anand Goswami,Jared Sterneckert +27 more
TL;DR: It is concluded that disruption of RBP homeostasis plays a critical role in FUS-ALS and can be treated by stimulating autophagy using small molecules to reduce cytoplasmic FUS, restore RBPHomeostasis and rescues motor function in vivo.