Z
Zohreh Hosseinzadeh
Researcher at University of Tübingen
Publications - 68
Citations - 1250
Zohreh Hosseinzadeh is an academic researcher from University of Tübingen. The author has contributed to research in topics: Voltage clamp & Cell membrane. The author has an hindex of 20, co-authored 66 publications receiving 1020 citations. Previous affiliations of Zohreh Hosseinzadeh include Leipzig University & Dresden University of Technology.
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Journal ArticleDOI
Regulation of the voltage gated K channel Kv1.3 by recombinant human klotho protein.
Ahmad Almilaji,Sabina Honisch,Guilai Liu,Bernat Elvira,Sumant Singh Ajay,Zohreh Hosseinzadeh,Musaab Ahmed,Carlos Munoz,Mentor Sopjani,Florian Lang +9 more
TL;DR: The present study explored the impact of alpha Klotho protein on the voltage gated K+ channel Kv1.3 currents and protein abundance in Jcam lymphoma cells, an effect depending on its β-glucuronidase activity.
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FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy.
Lara Marrone,Hannes C.A. Drexler,Jie Wang,Priyanka Tripathi,Tania Distler,Patrick Ruben Heisterkamp,Eric N. Anderson,Sukhleen Kour,Anastasia Moraiti,Shovamayee Maharana,Rajat Bhatnagar,T. Grant Belgard,Vadreenath Tripathy,Norman Kalmbach,Zohreh Hosseinzadeh,Valeria Crippa,Masin Abo-Rady,Florian Wegner,Angelo Poletti,Dirk Troost,Eleonora Aronica,Volker Busskamp,Joachim Weis,Udai Bhan Pandey,Anthony A. Hyman,Simon Alberti,Anand Goswami,Jared Sterneckert +27 more
TL;DR: It is concluded that disruption of RBP homeostasis plays a critical role in FUS-ALS and can be treated by stimulating autophagy using small molecules to reduce cytoplasmic FUS, restore RBPHomeostasis and rescues motor function in vivo.
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Upregulation of Na + ,Cl - -Coupled Betaine/ γ-Amino-Butyric Acid Transporter BGT1 by Tau Tubulin Kinase 2
TL;DR: Tau-tubulin-kinase 2 TTBK2 is a powerful stimulator of the osmolyte and GABA transporter BGT1 and significantly delayed the decline of transport following inhibition of carrier insertion with brefeldin A, indicating that wild-type T TBK2 increased carrier stability in the cell membrane.
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Upregulation of peptide transporters PEPT1 and PEPT2 by Janus kinase JAK2.
TL;DR: Regulation of the peptide transporters PEPt and PEPT2 does involve the Janus-activated kinase-2 JAK2, according to Ussing chamber experiments.
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Regulation of the glutamate transporters by JAK2.
Zohreh Hosseinzadeh,Shefalee K. Bhavsar,Mentor Sopjani,Ioana Alesutan,Ambrish Saxena,Miribane Dërmaku-Sopjani,Florian Lang +6 more
TL;DR: JAK2 is a novel powerful regulator of glutamate transporters and thus participates in the protection against excitotoxicity and does not appreciably affect carrier retrieval from the membrane.