V
Vadreenath Tripathy
Researcher at Dresden University of Technology
Publications - 4
Citations - 148
Vadreenath Tripathy is an academic researcher from Dresden University of Technology. The author has contributed to research in topics: Neurodegeneration & Stress granule. The author has an hindex of 3, co-authored 4 publications receiving 82 citations.
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Journal ArticleDOI
FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy.
Lara Marrone,Hannes C.A. Drexler,Jie Wang,Priyanka Tripathi,Tania Distler,Patrick Ruben Heisterkamp,Eric N. Anderson,Sukhleen Kour,Anastasia Moraiti,Shovamayee Maharana,Rajat Bhatnagar,T. Grant Belgard,Vadreenath Tripathy,Norman Kalmbach,Zohreh Hosseinzadeh,Valeria Crippa,Masin Abo-Rady,Florian Wegner,Angelo Poletti,Dirk Troost,Eleonora Aronica,Volker Busskamp,Joachim Weis,Udai Bhan Pandey,Anthony A. Hyman,Simon Alberti,Anand Goswami,Jared Sterneckert +27 more
TL;DR: It is concluded that disruption of RBP homeostasis plays a critical role in FUS-ALS and can be treated by stimulating autophagy using small molecules to reduce cytoplasmic FUS, restore RBPHomeostasis and rescues motor function in vivo.
Journal ArticleDOI
Hsp90-mediated regulation of DYRK3 couples stress granule disassembly and growth via mTORC1 signaling.
Laura Mediani,Francesco Antoniani,Veronica Galli,Jonathan Vinet,Arianna Dorotea Carrà,Ilaria Bigi,Vadreenath Tripathy,Tatiana Tiago,Marco Cimino,Giuseppina Leo,Triana Amen,Daniel Kaganovich,Cristina Cereda,Orietta Pansarasa,Jessica Mandrioli,Priyanka Tripathi,Dirk Troost,Eleonora Aronica,Johannes Buchner,Anand Goswami,Jared Sterneckert,Simon Alberti,Serena Carra +22 more
TL;DR: In this paper, the chaperone Hsp90 is required for stress granule dissolution, and the dual-specificity tyrosine-phosphorylation-regulated kinase 3 (DYRK3) is active and promotes SG disassembly, restoring mTORC1 signaling and translation.
Journal ArticleDOI
Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization.
Ian Casci,Karthik Krishnamurthy,Sukhleen Kour,Vadreenath Tripathy,Nandini Ramesh,Eric N. Anderson,Lara Marrone,Rogan A. Grant,Stacie Oliver,Lauren Gochenaur,Krishani Patel,Jared Sterneckert,Amanda M. Gleixner,Christopher J. Donnelly,Marc-David Ruepp,Antonella M. Sini,Emanuela Zuccaro,Maria Pennuto,Piera Pasinelli,Udai Bhan Pandey +19 more
TL;DR: It is demonstrated that muscleblind (Mbl) is a novel modifier of FUS-associated ALS, with knockdown of endogenous Mbl suppressing neuromuscular junction defects and motor dysfunctions associated with FUS expression in Drosophila, as well as restoring reduced SMN protein levels in mammalian neuronal and human iPSC-derived motor neurons.
Journal ArticleDOI
Viral Infections Exacerbate FUS-ALS Phenotypes in iPSC-Derived Spinal Neurons in a Virus Species-Specific Manner.
Jessica Bellmann,Anne Monette,Anne Monette,Vadreenath Tripathy,Anna Sójka,Masin Abo-Rady,Antje Janosh,Rajat Bhatnagar,Marc Bickle,Andrew J. Mouland,Andrew J. Mouland,Jared Sterneckert +11 more
TL;DR: It is found that rabies virus (RABV) spreads ALS phenotypes, including the formation of stress granules with aberrant composition due to increased levels of FUS protein, as well as neurodegeneration and reduced restriction activity by FUS mutations.