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Patrick T. Orr
Researcher at Yale University
Publications - 15
Citations - 1689
Patrick T. Orr is an academic researcher from Yale University. The author has contributed to research in topics: Hippocampal formation & Memory consolidation. The author has an hindex of 12, co-authored 15 publications receiving 1527 citations. Previous affiliations of Patrick T. Orr include Geisinger Health System & Bucknell University.
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Journal ArticleDOI
Neural Correlates of Food Addiction
Ashley N. Gearhardt,Sonja Yokum,Patrick T. Orr,Eric Stice,William R. Corbin,Kelly D. Brownell +5 more
TL;DR: Similar patterns of neural activation are implicated in addictive-like eating behavior and substance dependence: elevated activation in reward circuitry in response to food cues and reduced activation of inhibitory regions in responseto food intake.
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Estradiol-Induced Enhancement of Object Memory Consolidation Involves Hippocampal Extracellular Signal-Regulated Kinase Activation and Membrane-Bound Estrogen Receptors
Stephanie M. Fernandez,Michael C. Lewis,Angela S. Pechenino,Lauren L. Harburger,Patrick T. Orr,Jodi E. Gresack,Glenn E. Schafe,Karyn M. Frick +7 more
TL;DR: This study is the first to identify a specific molecular pathway by which E2 modulates memory and to demonstrate a novel role for membrane-bound ERs in mediating E2-induced improvements in hippocampal memory consolidation.
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The Cognitive and Behavioral Phenotype of the 16p11.2 Deletion in a Clinically Ascertained Population
Ellen Hanson,Raphael Bernier,Ken Porche,Frank I. Jackson,Robin P. Goin-Kochel,LeeAnne Green Snyder,Anne V. Snow,Arianne S. Wallace,Katherine L. Campe,Yuan Zhang,Qixuan Chen,Debra D'Angelo,Andres Moreno-De-Luca,Patrick T. Orr,K. B. Boomer,David W. Evans,Stephen M. Kanne,Leandra N. Berry,Fiona Miller,Jennifer Olson,Elliot Sherr,Christa Lese Martin,David H. Ledbetter,John E. Spiro,Wendy K. Chung +24 more
TL;DR: Clinically referred individuals with the 16p11.2 deletion have high rates of psychiatric and developmental disorders and provide a genetically well-defined group to study the emergence of developmental difficulties, particularly associated with the broader autism phenotype.
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Estradiol-Induced Object Memory Consolidation in Middle-Aged Female Mice Requires Dorsal Hippocampal Extracellular Signal-Regulated Kinase and Phosphatidylinositol 3-Kinase Activation
TL;DR: It is demonstrated for the first time that activation of dorsal hippocampal PI3K/Akt and ERK signaling pathways is necessary for E2 to enhance object recognition memory in middle-aged females and that the inability of E1 to activate these pathways may underlie its failure to enhancing object recognition in aged females.
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Estradiol-induced object recognition memory consolidation is dependent on activation of mTOR signaling in the dorsal hippocampus.
TL;DR: It is demonstrated for the first time that activation of the dorsal hippocampal mTOR signaling pathway is necessary for E(2) to enhance object recognition memory consolidation and that E( 2)-induced mTOR activation is dependent on upstream activation of ERK and PI3K signaling.