E
Elgene Lim
Researcher at University of New South Wales
Publications - 149
Citations - 9133
Elgene Lim is an academic researcher from University of New South Wales. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 36, co-authored 120 publications receiving 6769 citations. Previous affiliations of Elgene Lim include University of Melbourne & Harvard University.
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Journal ArticleDOI
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
Elgene Lim,Elgene Lim,François Vaillant,Di Wu,Di Wu,Natasha C. Forrest,Bhupinder Pal,Adam H. Hart,Marie Liesse Asselin-Labat,David E. Gyorki,David E. Gyorki,Teresa Ward,Audrey Partanen,Frank Feleppa,Lily I. Huschtscha,Heather Thorne,Stephen B. Fox,Max Yan,Juliet D. French,Melissa A. Brown,Gordon K. Smyth,Jane E. Visvader,Geoffrey J. Lindeman,Geoffrey J. Lindeman,Geoffrey J. Lindeman +24 more
TL;DR: It is found that breast tissue from BRCA1 mutation carriers harbors an expanded luminal progenitor population that shows factor-independent growth in vitro, and the findings suggest that an aberrant luminalprogenitor population is a target for transformation in BRCa1-associated basal tumors.
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XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway
Xi Chen,Dimitrios Iliopoulos,Dimitrios Iliopoulos,Qing Zhang,Qianzi Tang,Qianzi Tang,Matthew B. Greenblatt,Maria Hatziapostolou,Maria Hatziapostolou,Elgene Lim,Wai Leong Tam,Min Ni,Yiwen Chen,Junhua Mai,Haifa Shen,Haifa Shen,Dorothy Hu,Stanley Adoro,Bella Hu,Minkyung Song,Chen Tan,Melissa D. Landis,Mauro Ferrari,Mauro Ferrari,Sandra J. Shin,Myles Brown,Jenny C. Chang,X. Shirley Liu,Laurie H. Glimcher +28 more
TL;DR: It is reported that XBP1 is activated in TNBC and has a pivotal role in the tumorigenicity and progression of this human breast cancer subtype, and targeting this pathway may offer alternative treatment strategies for this aggressive subtype of breast cancer.
Journal ArticleDOI
EMT, cell plasticity and metastasis
TL;DR: Recent insights into the function of the EMT and cancer cell plasticity during cancer progression are discussed, with a focus on their role in promoting successful completion of the later stages of the metastatic cascade.
Journal ArticleDOI
ROAST: rotation gene set tests for complex microarray experiments
Di Wu,Elgene Lim,François Vaillant,Marie Liesse Asselin-Labat,Jane E. Visvader,Jane E. Visvader,Gordon K. Smyth,Gordon K. Smyth +7 more
TL;DR: ROAST is a statistically rigorous gene set test that allows for gene-wise correlation while being applicable to almost any experimental design, and uses rotation, a Monte Carlo technology for multivariate regression, instead of permutation.
Journal ArticleDOI
Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways
Elgene Lim,Elgene Lim,Di Wu,Di Wu,Bhupinder Pal,Toula Bouras,Marie Liesse Asselin-Labat,François Vaillant,Hideo Yagita,Geoffrey J. Lindeman,Geoffrey J. Lindeman,Geoffrey J. Lindeman,Gordon K. Smyth,Gordon K. Smyth,Jane E. Visvader,Jane E. Visvader +15 more
TL;DR: The conservation of genes and pathways across species further validates the use of the mouse as a model to study mammary gland development and highlights pathways that are likely to govern cell-fate decisions and differentiation.