H
Hans-Anton Lehr
Researcher at University Hospital of Lausanne
Publications - 144
Citations - 12930
Hans-Anton Lehr is an academic researcher from University Hospital of Lausanne. The author has contributed to research in topics: Colitis & Breast cancer. The author has an hindex of 51, co-authored 142 publications receiving 11750 citations. Previous affiliations of Hans-Anton Lehr include University of Mainz & University of Lausanne.
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Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo.
Raja Atreya,Jonas Mudter,Susetta Finotto,Jürgen Müllberg,Thomas Jostock,Stefan Wirtz,M Schütz,Brigitte Bartsch,Martin H. Holtmann,Christoph Becker,Dennis Strand,J Czaja,Joerg F. Schlaak,Hans-Anton Lehr,Frank Autschbach,G. Schürmann,N Nishimoto,Kazuyuki Yoshizaki,Hiroshi Ito,Tadamitsu Kishimoto,Peter R. Galle,Stefan Rose-John,Markus F. Neurath +22 more
TL;DR: Assessment of the contribution of the pro-inflammatory cytokine interleukin (IL)-6 to the increased resistance of mucosal T cells against apoptosis in Crohn disease indicates that a pathway of T-cell activation driven by IL-6–sIL-6R contributes to the perpetuation of chronic intestinal inflammation.
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Interactions between cancer stem cells and their niche govern metastatic colonization
Ilaria Malanchi,Albert Santamaria-Martínez,Evelyn Susanto,Hong Peng,Hong Peng,Hans-Anton Lehr,Jean-François Delaloye,Joerg Huelsken +7 more
TL;DR: It is suggested that the education of stromal cells by infiltrating tumour cells is an important step in metastatic colonization and that preventing de novo niche formation may be a novel strategy for the treatment of metastatic disease.
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STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
Geethanjali Pickert,Clemens Neufert,Moritz Leppkes,Yan Zheng,Nadine Wittkopf,Moritz Warntjen,Hans-Anton Lehr,Sebastian Hirth,Benno Weigmann,Stefan Wirtz,Wenjun Ouyang,Markus F. Neurath,Christoph Becker +12 more
TL;DR: The data suggest that intestinal epithelial STAT3 activation regulates immune homeostasis in the gut by promoting IL-22–dependent mucosal wound healing and Gene chip analysis indicated that STAT3 regulates the cellular stress response, apoptosis, and pathways associated with wound healing in IECs.
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Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinicopathologic study of 26 cases and review of the literature.
TL;DR: It is concluded that PEComas of soft tissue and gynecologic origin may be classified as “benign,’ “of uncertain malignant potential,” or “malignant.”
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The humoral immune system has a key prognostic impact in node-negative breast cancer.
Marcus Schmidt,D Böhm,Christian von Törne,Eric Steiner,Alexander Puhl,Henryk Pilch,Hans-Anton Lehr,Jan G. Hengstler,Heinz Kölbl,Mathias Gehrmann +9 more
TL;DR: It is shown in three cohorts of untreated, node-negative breast cancer patients that the humoral immune system plays a pivotal role in metastasis-free survival of carcinomas of the breast.