D
David J. Segal
Researcher at University of California, Davis
Publications - 173
Citations - 13467
David J. Segal is an academic researcher from University of California, Davis. The author has contributed to research in topics: Zinc finger & Gene. The author has an hindex of 55, co-authored 162 publications receiving 11965 citations. Previous affiliations of David J. Segal include University of Melbourne & University of Utah.
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Journal ArticleDOI
TLR3 deficiency in patients with herpes simplex encephalitis.
Shen-Ying Zhang,Shen-Ying Zhang,Emmanuelle Jouanguy,Emmanuelle Jouanguy,Sophie Ugolini,Asma Smahi,Gaelle Elain,Pedro Romero,David J. Segal,Vanessa Sancho-Shimizu,Lazaro Lorenzo,Anne Puel,Capucine Picard,Ariane Chapgier,Sabine Plancoulaine,Matthias Titeux,Céline Cognet,Horst von Bernuth,Cheng-Lung Ku,Armanda Casrouge,Xin Xin Zhang,Luis B. Barreiro,Joshua N. Leonard,Claire Hamilton,Pierre Lebon,Bénédicte Héron,Louis Vallée,Lluis Quintana-Murci,Alain Hovnanian,Flore Rozenberg,Eric Vivier,Frederic Geissmann,Marc Tardieu,Laurent Abel,Jean-Laurent Casanova +34 more
TL;DR: Human TLR3 appears to be redundant in host defense to most microbes but is vital for natural immunity to HSV-1 in the CNS, which suggests that neurotropic viruses have contributed to the evolutionary maintenance ofTLR3.
Journal ArticleDOI
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
András Kotschy,Szlávik Zoltán,James A. H. Murray,James Edward Paul Davidson,Ana Leticia Maragno,Gaëtane Le Toumelin-Braizat,Maïa Chanrion,Gemma L. Kelly,Gemma L. Kelly,Jia-Nan Gong,Jia-Nan Gong,Donia M Moujalled,Alain Bruno,Csékei Márton,Attila Paczal,Zoltán B. Szabó,Szabolcs Sipos,Gabor Radics,Proszenyák Ágnes,Balázs Bálint,Levente Ondi,Gábor Blasko,Alan P. Robertson,Allan E. Surgenor,Pawel Dokurno,Chen I-Jen,Natalia Matassova,Julia Smith,C. Pedder,Chris Graham,Aurélie Studeny,Gaëlle Lysiak-Auvity,Anne-Marie Girard,Fabienne Gravé,David J. Segal,David J. Segal,Chris D. Riffkin,Chris D. Riffkin,Giovanna Pomilio,Laura C. A. Galbraith,Laura C. A. Galbraith,Brandon J. Aubrey,Brandon J. Aubrey,Brandon J. Aubrey,Margs S. Brennan,Margs S. Brennan,Marco J Herold,Marco J Herold,Catherine Chang,Catherine Chang,Ghislaine Guasconi,Nicolas Cauquil,Fabien Melchiore,Nolwen Guigal-Stephan,Brian Lockhart,Frédéric Colland,John A. Hickman,Andrew W. Roberts,David C.S. Huang,David C.S. Huang,Andrew H. Wei,Andrew H. Wei,Andreas Strasser,Andreas Strasser,Guillaume Lessene,Guillaume Lessene,Olivier Geneste +66 more
TL;DR: It is demonstrated that S63845 potently kills MCL1-dependent cancer cells, including multiple myeloma, leukaemia and lymphoma cells, by activating the BAX/BAK-dependent mitochondrial apoptotic pathway.
Journal ArticleDOI
Stimulation of homologous recombination through targeted cleavage by chimeric nucleases.
Marina Bibikova,Dana Carroll,David J. Segal,Jonathan K. Trautman,Jeffrey B. Smith,Yang-Gyun Kim,Srinivasan Chandrasegaran +6 more
TL;DR: Chimeric nucleases that are hybrids between a nonspecific DNA cleavage domain and a zinc finger DNA recognition domain were tested for their ability to find and cleave their target sites in living cells, and two chimeric enzymes with different binding specificities could collaborate to stimulate recombination when their individual sites were appropriately placed.
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Toward controlling gene expression at will: Specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks
TL;DR: It is demonstrated that both gene repression and activation can be achieved by targeting designed proteins to a single site within the transcribed region of a gene, indicating that gene-specific transcriptional regulators of the type described here will find diverse applications in gene therapy, functional genomics, and the generation of transgenic organisms.
Journal ArticleDOI
Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases.
TL;DR: A structure-based approach to reducing off-target cleavage of zinc-finger nucleases by preventing homodimerization and lowering the dimerization energy is described, which increased the specificity of target site cleavage.