Showing papers by "Patrizia Rizzu published in 2004"
TL;DR: The view that different neurodegenerative diseases may have similar pathological mechanisms, and that these processes likely include DJ‐1, is extended to include tauopathies.
Abstract: Two novel mutations recently have been identified in the DJ-1 gene that cause a new form of autosomal recessive, early-onset parkinsonism. Because the pathological role of this protein is unknown, we examined the issue here and report the colocalization of DJ-1 protein within a subset of pathological tau inclusions in a diverse group of neurodegenerative disorders known as tauopathies. Our study extends the view that different neurodegenerative diseases may have similar pathological mechanisms, and that these processes likely include DJ-1.
142 citations