Journal ArticleDOI
DJ-1 colocalizes with tau inclusions: a link between parkinsonism and dementia.
Patrizia Rizzu,Patrizia Rizzu,David A. Hinkle,Victoria Zhukareva,Vincenzo Bonifati,Vincenzo Bonifati,Lies-Anne Severijnen,Daniel Martinez,Rivka Ravid,Wouter Kamphorst,James Eberwine,Virginia M.-Y. Lee,John Q. Trojanowski,Peter Heutink,Peter Heutink +14 more
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TLDR
The view that different neurodegenerative diseases may have similar pathological mechanisms, and that these processes likely include DJ‐1, is extended to include tauopathies.Abstract:
Two novel mutations recently have been identified in the DJ-1 gene that cause a new form of autosomal recessive, early-onset parkinsonism. Because the pathological role of this protein is unknown, we examined the issue here and report the colocalization of DJ-1 protein within a subset of pathological tau inclusions in a diverse group of neurodegenerative disorders known as tauopathies. Our study extends the view that different neurodegenerative diseases may have similar pathological mechanisms, and that these processes likely include DJ-1.read more
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Molecular pathophysiology of parkinson's disease
TL;DR: Increasing evidence indicates that deficits in mitochondrial function, oxidative and nitrosative stress, the accumulation of aberrant or misfolded proteins, and ubiquitin-proteasome system dysfunction may represent the principal molecular pathways or events that commonly underlie the pathogenesis of sporadic and familial forms of PD.
Journal ArticleDOI
Expanding insights of mitochondrial dysfunction in Parkinson's disease
TL;DR: How DJ1, PINK1 and OMI/HTRA2 fit into and enhance the understanding of the role of mitochondrial dysfunction in Parkinson's disease are reviewed, and how oxidative stress might be a potential unifying factor in the aetiopathogenesis of the disease is considered.
Journal ArticleDOI
Genetics of Parkinson disease: paradigm shifts and future prospects.
TL;DR: Genetic insights provide the rationale for new strategies for prevention or therapy, and have led to animal models of disease in which these strategies can be tested.
Journal ArticleDOI
The biochemistry of parkinson's disease*
TL;DR: Several genes have been identified for monogenic disorders that variably resemble Parkinson's disease, but it is not yet fully resolved how the recessive genes relate to alpha-synuclein, or whether they represent different ways to induce a similar phenotype.
Journal ArticleDOI
Oxidative Damage of DJ-1 Is Linked to Sporadic Parkinson and Alzheimer Diseases
Joungil Choi,M. Cameron Sullards,James A. Olzmann,Howard D. Rees,Susan E Weintraub,David E. Bostwick,Marla Gearing,Allan I. Levey,Lih-Shen Chin,Lian Li +9 more
TL;DR: It is reported thatDJ-1 is oxidatively damaged in the brains of patients with idiopathic PD and AD and association of oxidative damage to DJ-1 with sporadic PD andAD is indicated.
References
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Journal ArticleDOI
Mutation in the α-synuclein gene identified in families with Parkinson's disease
Mihael H. Polymeropoulos,Christian Lavedan,Elisabeth Leroy,Susan E. Ide,Anindya Dehejia,Amalia Dutra,Brian L. Pike,Holly Root,Jeffrey Rubenstein,Rebecca Boyer,Edward S. Stenroos,Settara C. Chandrasekharappa,Aglaia Athanassiadou,Theodore Papapetropoulos,William G. Johnson,Alice Lazzarini,Roger C. Duvoisin,Giuseppe Di Iorio,Lawrence I. Golbe,Robert L. Nussbaum +19 more
TL;DR: A mutation was identified in the α-synuclein gene, which codes for a presynaptic protein thought to be involved in neuronal plasticity, in the Italian kindred and in three unrelated families of Greek origin with autosomal dominant inheritance for the PD phenotype.
Journal ArticleDOI
α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies
TL;DR: It is shown thatLewy bodies and Lewy neurites from Parkinson’s disease and dementia with Lewy bodies are stained strongly by antibodies directed against amino- terminal and carboxyl-terminal sequences of α-synuclein, showing the presence of full- length or close to full-length α- synuclein.
Journal ArticleDOI
Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism
Vincenzo Bonifati,Vincenzo Bonifati,Patrizia Rizzu,Marijke J. van Baren,Onno Schaap,Guido J. Breedveld,Elmar Krieger,Marieke C. J. Dekker,Ferdinando Squitieri,Pablo Ibanez,Marijke Joosse,Jeroen W.F. van Dongen,Nicola Vanacore,Nicola Vanacore,John C. van Swieten,Alexis Brice,Giuseppe Meco,Cornelia M. van Duijn,Ben A. Oostra,Peter Heutink +19 more
TL;DR: It is shown that DJ-1 mutations are associated with PARK7, a monogenic form of human parkinsonism, and these findings indicate that loss ofDJ-1 function leads to neurodegeneration.
Journal ArticleDOI
DJ-1 Positively Regulates the Androgen Receptor by Impairing the Binding of PIASxα to the Receptor
Kazuko Takahashi,Takahiro Taira,Takeshi Niki,Chiaki Seino,Sanae M.M. Iguchi-Ariga,Hiroyoshi Ariga +5 more
TL;DR: Results indicate that DJ-1 is a positive regulator of the androgen receptor, which is a novel candidate of the oncogene product that transformed mouse NIH3T3 cells in cooperation with an activated ras.
Journal ArticleDOI
DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin.
TL;DR: It is shown that DJ-1 protein of pI 5.8 increases concomitantly with endogenous production of reactive oxygen species (ROS) under endotoxin-induced inflammatory conditions, and implies thatDJ-1 may be useful as an endogenous indicator of oxidative stress status in vivo.
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Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism
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