P
Paul A. Baars
Researcher at University of Amsterdam
Publications - 36
Citations - 4529
Paul A. Baars is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Cytotoxic T cell & Interleukin 21. The author has an hindex of 21, co-authored 34 publications receiving 4327 citations.
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Journal ArticleDOI
Phenotypic and Functional Separation of Memory and Effector Human CD8+ T Cells
Dörte Hamann,Paul A. Baars,M.H.G. Rep,Berend Hooibrink,Susana R. Kerkhof-Garde,Michèl R. Klein,René A. W. van Lier +6 more
TL;DR: In this article, two discrete primed subpopulations are found within the circulating human CD8+ T cell subset, i.e., CD45RA−CD45R0+ cells and CD27−CD27− cells.
Journal ArticleDOI
CD20 deficiency in humans results in impaired T cell–independent antibody responses
Taco W. Kuijpers,Richard J. Bende,Paul A. Baars,Annette Grummels,Ingrid A. M. Derks,Koert M. Dolman,Tim Beaumont,Thomas F. Tedder,Carel J. M. van Noesel,Eric Eldering,René A. W. van Lier +10 more
TL;DR: The role of CD20 in human B cell physiology has remained elusive as mentioned in this paper, and a juvenile patient with CD20 deficiency due to a homozygous mutation in a splice junction of the CD20 gene (also known as MS4A1) has been described.
Journal Article
Regulation of CD27 expression on subsets of mature T-lymphocytes.
TL;DR: Comparison of CD27 expression with its structural homologue FAS/APO-1 showed that down-regulation after prolonged activation is not a general feature of TNF/NGF-R family members and the CD27 negative phenotype seems a stable reflection of differentiation rather than of activation.
Journal ArticleDOI
Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFNgamma-mediated B cell depletion.
Ramon Arens,Kiki Tesselaar,Paul A. Baars,Gijs M.W. van Schijndel,Jenny Hendriks,Steven T. Pals,Paul Krimpenfort,Jannie Borst,Marinus H. J. van Oers,René A. W. van Lier +9 more
TL;DR: It is concluded that apart from its role in controlling the size of the activated T cell pool, CD27 ligation contributes to immunity by facilitating effector T cell differentiation.
Journal ArticleDOI
Differentiation of cytomegalovirus-specific CD8(+) T cells in healthy and immunosuppressed virus carriers.
L.E. Gamadia,R.J Rentenaar,Paul A. Baars,Ester B. M. Remmerswaal,S. Surachno,J. F. L. Weel,Mireille Toebes,T.N.J. Schumacher,R.J.M. (Ineke) ten Berge,R. A. W. Van Lier +9 more
TL;DR: Data show that in response to immunosuppressive medication quantitative and qualitative changes occur in the CD8(+) T-cell compartment, and these adaptations may be instrumental to maintain CMV latency.