Berend Hooibrink

TL;DR: In this article, two discrete primed subpopulations are found within the circulating human CD8+ T cell subset, i.e., CD45RA−CD45R0+ cells and CD27−CD27− cells.

TL;DR: The design, synthesis and application of two fluorescent activity-based probes allowing highly specific labeling of active GBA molecules in vitro and in cultured cells and mice in vivo are reported, allowing them to study inhibitors and tentative chaperones in living cells.

TL;DR: It is suggested that upon renewed as well as chronic antigenic stimulation in vivo, memory T cells acquire the CD45RA−CD27− phenotype and that, as a consequence, in this subset functionally differentiated CD4+ T cells are compartmentalized.

TL;DR: All human CD8+ T-cell subsets had the ability to respond to IL-15, which suggests a generic influence of this cytokine on CD8- T- cell homeostasis in man.

TL;DR: It is shown that the absence or presence of CD103 was a stable trait when purified CD103− and CD103+CD8+ T cell subsets were stimulated with a combination of CD3 and CD28 mAbs, and that human alloantigen-induced CD103-induced T cells possess functional features of regulatory T cells.