Fan Zhong

TL;DR: This work systematically analyzed binding specificities of full-length transcription factors and extended DNA binding domains to unmethylated and CpG-methylated DNA by using methylation-sensitive SELEX (systematic evolution of ligands by exponential enrichment).

TL;DR: Current advances in endogenous β cell regeneration are understood, potential new strategies for the treatment of diabetes focused on cell therapy are provided, and various factors involved in regulation ofβ cell regeneration under physiological or pathological conditions are discussed.

TL;DR: It is found that the protein abundance plays a decisive role and hydrophobicity has a greater influence than molecular weight and isoelectric point on protein detectability and the enrichment strategy used for low-abundant transcription factors helped to identify missing proteins.

TL;DR: A high throughput process including subcellular fractionation and multiple protein separation and identification technology allowed us to establish the protein expression profile of human fetal liver, which was composed of at least 2,495 distinct proteins and 568 non-isoform groups identified from 64,960 peptides and 24,454 distinct peptides.

TL;DR: It is shown that a 538 kb deletion of the entire MYC upstream super-enhancer region in mice results in 50% to 80% decrease in Myc expression in multiple tissues, and indicates that targeting the activity of this element is a promising strategy of cancer chemoprevention and therapy.