J
Jian Yan
Researcher at City University of Hong Kong
Publications - 34
Citations - 5439
Jian Yan is an academic researcher from City University of Hong Kong. The author has contributed to research in topics: Enhancer & Transcription factor. The author has an hindex of 17, co-authored 31 publications receiving 4488 citations. Previous affiliations of Jian Yan include National Institutes of Health & Science for Life Laboratory.
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Journal ArticleDOI
DNA-Binding Specificities of Human Transcription Factors
Arttu Jolma,Jian Yan,Tom Whitington,Jarkko Toivonen,Kazuhiro R. Nitta,Pasi Rastas,Ekaterina Morgunova,Martin Enge,Mikko Taipale,Gong-Hong Wei,Kimmo Palin,Juan M. Vaquerizas,Renaud Vincentelli,Nicholas M. Luscombe,Timothy P. Hughes,Patrick Lemaire,Esko Ukkonen,Teemu Kivioja,Teemu Kivioja,Jussi Taipale,Jussi Taipale +20 more
TL;DR: Global analysis of the data revealed that homodimer orientation and spacing preferences, and base-stacking interactions, have a larger role in TF-DNA binding than previously appreciated.
Journal ArticleDOI
Impact of cytosine methylation on DNA binding specificities of human transcription factors.
Yimeng Yin,Ekaterina Morgunova,Arttu Jolma,Eevi Kaasinen,Biswajyoti Sahu,Syed Khund-Sayeed,Pratyush Kumar Das,Teemu Kivioja,Kashyap Dave,Fan Zhong,Kazuhiro R. Nitta,Minna Taipale,Alexander Popov,Paul A. Ginno,Silvia Domcke,Silvia Domcke,Jian Yan,Dirk Schübeler,Dirk Schübeler,Charles Vinson,Jussi Taipale,Jussi Taipale +21 more
TL;DR: This work systematically analyzed binding specificities of full-length transcription factors and extended DNA binding domains to unmethylated and CpG-methylated DNA by using methylation-sensitive SELEX (systematic evolution of ligands by exponential enrichment).
Journal ArticleDOI
MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas.
Netta Mäkinen,Miika Mehine,Jaana Tolvanen,Eevi Kaasinen,Yang Li,Heli J. Lehtonen,Massimiliano Gentile,Jian Yan,Martin Enge,Minna Taipale,Minna Taipale,Mervi Aavikko,Riku Katainen,Elina Virolainen,Tom Böhling,Tom Böhling,Taru A. Koski,Virpi Launonen,Jari Sjöberg,Jussi Taipale,Jussi Taipale,Pia Vahteristo,Lauri A. Aaltonen +22 more
TL;DR: It is determined that MED12 is altered in 70% (159 of 225) of tumors from a total of 80 patients, and aberrant function of this region of MED12 contributes to tumorigenesis.
Journal ArticleDOI
Genome-Wide Analysis of ETS-Family DNA-Binding In Vitro and In Vivo
Gong-Hong Wei,Gwenael Badis,Michael F. Berger,Teemu Kivioja,Teemu Kivioja,Kimmo Palin,Martin Enge,Martin Bonke,Arttu Jolma,Markku Varjosalo,Andrew R. Gehrke,Jian Yan,Shaheynoor Talukder,Mikko P. Turunen,Mikko Taipale,Hendrik G. Stunnenberg,Esko Ukkonen,Timothy P. Hughes,Martha L. Bulyk,Jussi Taipale,Jussi Taipale +20 more
TL;DR: The results indicate that even relatively small differences in in vitro binding specificity of a TF contribute to site selectivity in vivo, and this work identifies amino‐acid residues that are critical for the differences in specificity between all the classes.
Journal ArticleDOI
The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling
Sari Tuupanen,Mikko P. Turunen,Rainer Lehtonen,Outi Hallikas,Sakari Vanharanta,Sakari Vanharanta,Teemu Kivioja,Mikael Björklund,Gong-Hong Wei,Jian Yan,Iina Niittymäki,Jukka-Pekka Mecklin,Heikki Järvinen,Ari Ristimäki,Ari Ristimäki,Mariachiara Di-Bernardo,Phil East,Luis G. Carvajal-Carmona,Richard S. Houlston,Ian Tomlinson,Kimmo Palin,Kimmo Palin,Esko Ukkonen,Auli Karhu,Jussi Taipale,Lauri A. Aaltonen +25 more
TL;DR: It is reported here that the risk allele G shows copy number increase during CRC development and provides evidence that the common CRC predisposition associated with 8q24 arises from enhanced responsiveness to Wnt signaling.