B
Biswajyoti Sahu
Researcher at University of Helsinki
Publications - 38
Citations - 3086
Biswajyoti Sahu is an academic researcher from University of Helsinki. The author has contributed to research in topics: Androgen receptor & Chromatin. The author has an hindex of 17, co-authored 35 publications receiving 2335 citations. Previous affiliations of Biswajyoti Sahu include Helsinki University Central Hospital & University of Cambridge.
Papers
More filters
Journal ArticleDOI
Impact of cytosine methylation on DNA binding specificities of human transcription factors.
Yimeng Yin,Ekaterina Morgunova,Arttu Jolma,Eevi Kaasinen,Biswajyoti Sahu,Syed Khund-Sayeed,Pratyush Kumar Das,Teemu Kivioja,Kashyap Dave,Fan Zhong,Kazuhiro R. Nitta,Minna Taipale,Alexander Popov,Paul A. Ginno,Silvia Domcke,Silvia Domcke,Jian Yan,Dirk Schübeler,Dirk Schübeler,Charles Vinson,Jussi Taipale,Jussi Taipale +21 more
TL;DR: This work systematically analyzed binding specificities of full-length transcription factors and extended DNA binding domains to unmethylated and CpG-methylated DNA by using methylation-sensitive SELEX (systematic evolution of ligands by exponential enrichment).
Journal ArticleDOI
Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer
Biswajyoti Sahu,Marko Laakso,Kristian Ovaska,Tuomas Mirtti,Tuomas Mirtti,Johan Lundin,Antti Rannikko,Anna Sankila,Juha-Pekka Turunen,Mikael Lundin,Juho Konsti,Tiina Vesterinen,Stig Nordling,Olli Kallioniemi,Sampsa Hautaniemi,Olli A. Jänne,Olli A. Jänne +16 more
TL;DR: A new paradigm for the forkhead protein FoxA1 action in androgen signalling is reported, which was associated with poor prognosis, whereas low FoxA 1 level, even in the presence of high AR expression, predicted good prognosis.
Journal ArticleDOI
The interaction landscape between transcription factors and the nucleosome.
Fangjie Zhu,Lucas Farnung,Eevi Kaasinen,Biswajyoti Sahu,Yimeng Yin,Bei Wei,Svetlana O. Dodonova,Kazuhiro R. Nitta,Ekaterina Morgunova,Minna Taipale,Minna Taipale,Patrick Cramer,Patrick Cramer,Jussi Taipale,Jussi Taipale,Jussi Taipale +15 more
TL;DR: This work reveals notable differences in the binding of transcription factors to free and nucleosomal DNA, and uncovers a diverse interaction landscape between transcription factors and the nucleosome.
Journal ArticleDOI
Androgen-regulated miR-32 targets BTG2 and is overexpressed in castration-resistant prostate cancer
Sanni E. Jalava,Alfonso Urbanucci,Leena Latonen,Kati K. Waltering,Biswajyoti Sahu,Olli A. Jänne,Janne Seppälä,Harri Lähdesmäki,Teuvo L.J. Tammela,Tapio Visakorpi +9 more
TL;DR: Androgen-regulated miR-32 is overexpressed in CRPC, leading to reduced expression of BTG2, a potential marker for aggressive disease and is a putative drug target in PC.
Journal ArticleDOI
Increased Expression of Androgen Receptor Sensitizes Prostate Cancer Cells to Low Levels of Androgens
Kati K. Waltering,Merja A. Helenius,Biswajyoti Sahu,Visa Manni,Marika J. Linja,Olli A. Jänne,Tapio Visakorpi +6 more
TL;DR: The results show that overexpression of AR sensitizes castration-resistant prostate cancer cells to the low levels of androgens, indicating the central role of AR in the overall regulation of gene expression in prostatecancer cells.