P
Paul Coucke
Researcher at Ghent University
Publications - 238
Citations - 13452
Paul Coucke is an academic researcher from Ghent University. The author has contributed to research in topics: Pseudoxanthoma elasticum & Gene. The author has an hindex of 55, co-authored 212 publications receiving 11905 citations. Previous affiliations of Paul Coucke include Ghent University Hospital & Baylor College of Medicine.
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Journal ArticleDOI
Comprehensive in silico Study of GLUT10: Prediction of Possible Substrate Binding Sites and Interacting Molecules
Mohammad Jakir Hosen,Mahmudul Hasan,Sourav Chakraborty,Ruhshan Ahmed Abir,Abdullah Zubaer,Paul Coucke +5 more
TL;DR: Virtual screening of all metabolites from the Human Serum Metabolome Database against the GLUT10 homology model disclosed possible substrates and interacting molecules forGLUT10, which are mostly lipid and biliary secretion compounds, some of which are found to be involved directly or partially in ATS progress.
Journal ArticleDOI
Clinical and subclinical findings in heterozygous ABCC6 carriers: results from a Belgian cohort and clinical practice guidelines.
Lukas Nollet,Laurence Campens,Julie De Zaeytijd,Bart P. Leroy,Dimitri Hemelsoet,Paul Coucke,Olivier Vanakker +6 more
TL;DR: In this article, a large Belgian cohort of heterozygous ABCC6 carriers with comprehensive clinical, biochemical and imaging data was evaluated using clinical (eg., detailed ophthalmological examinations), biochemical, imaging (eg, cardiovascular and abdominal ultrasound) and genetic data.
Journal ArticleDOI
Erratum: Mutations in ATP6V1E1 or ATP6V1A Cause Autosomal-Recessive Cutis Laxa (The American Journal of Human Genetics (2017) 100(2) (216–227), (S0002929716305341), (10.1016/j.ajhg.2016.12.010))
Tim Van Damme,Thatjana Gardeitchik,Miski Mohamed,Sergio Guerrero-Castillo,Peter Freisinger,Brecht Guillemyn,Ariana Kariminejad,Daisy Dalloyaux,Sanne van Kraaij,Dirk Lefeber,Delfien Syx,Wouter Steyaert,Riet De Rycke,Alexander Hoischen,Erik-Jan Kamsteeg,Sunnie Wong,Monique van Scherpenzeel,Payman Jamali,Ulrich Brandt,Leo G.J. Nijtmans,G. Christoph Korenke,Brian H.Y. Chung,Christopher C.Y. Mak,Ingrid Hausser,Uwe Kornak,Björn Fischer-Zirnsak,Tim M. Strom,Thomas Meitinger,Yasemin Alanay,Gülen Eda Utine,Kai Ching Peter Leung,Siavash Ghaderi-Sohi,Paul Coucke,Sofie Symoens,Anne De Paepe,Christian Thiel,Tobias B. Haack,Fransiska Malfait,Eva Morava,Bert Callewaert,Ron A. Wevers +40 more
Journal ArticleDOI
CRISPR-SID: Identifying EZH2 as a druggable target for desmoid tumors via in vivo dependency mapping.
Thomas Naert,Dieter Tulkens,Tom Van Nieuwenhuysen,Joanna Przybyl,Suzan Demuynck,Matt van de Rijn,Mushriq Al-Jazrawe,Benjamin A. Alman,Paul Coucke,Kim De Leeneer,Christian Vanhove,Savvas N. Savvides,David Creytens,Kris Vleminckx +13 more
TL;DR: In this paper, the authors used multiplexed CRISPR/Cas9 genome editing in these models to simultaneously target a tumor suppressor gene ( apc) and candidate dependency genes.
Posted ContentDOI
SLC2A knockout mice deficient in ascorbic acid synthesis recapitulate aspects of arterial tortuosity syndrome and display mitochondrial respiration defects
Annekatrien Boel,Joyce Burger,Marine Vanhomwegen,Aude Beyens,Marjolijn Renard,Sander Barnhoorn,Christophe Casteleyn,Dieter P. Reinhardt,Benedicte Descamps,Christian Vanhove,Ingrid van der Pluijm,Paul Coucke,Andy Willaert,Jeroen Essers,Bert Callewaert +14 more
TL;DR: Evidence is added that ATS is an ascorbate compartmentalization disorder, but additional factors underlying the observed phenotype in humans remain to be determined.