P
Paul Digard
Researcher at University of Edinburgh
Publications - 153
Citations - 15134
Paul Digard is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Influenza A virus & Virus. The author has an hindex of 53, co-authored 138 publications receiving 13670 citations. Previous affiliations of Paul Digard include University of Warwick & Harvard University.
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Journal ArticleDOI
A Complicated Message: Identification of a Novel PB1-Related Protein Translated from Influenza A Virus Segment 2 mRNA
Helen M. Wise,Ágnes Foeglein,Jiechao Sun,Rosa M. Dalton,Sheetal Patel,Wendy A. Howard,Emma C. Anderson,Wendy S. Barclay,Paul Digard +8 more
TL;DR: The influenza A virus proteome includes a 12th primary translation product that (similarly to PB1-F2) is nonessential for virus viability but whose loss, in particular genetic backgrounds, is detrimental to virus replication.
Journal ArticleDOI
Genome packaging in influenza A virus
TL;DR: It is concluded that the vast majority of virions contain no more than eight segments and that a specific mechanism does indeed function to select one copy of each vRNA.
Journal ArticleDOI
Interaction of the influenza virus nucleoprotein with the cellular CRM1-mediated nuclear export pathway.
Debra Elton,Martha Simpson-Holley,Kate Archer,Liz Medcalf,Roger Hallam,John W. McCauley,Paul Digard +6 more
TL;DR: It is found that the drug leptomycin B (LMB), which specifically inactivates the cellular CRM1 polypeptide, caused nuclear retention of NP in virus-infected cells, indicating a role for theCRM1 nuclear export pathway in RNP egress.
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Identification of a novel splice variant form of the influenza A virus M2 ion channel with an antigenically distinct ectodomain.
Helen M. Wise,Edward C. Hutchinson,Brett W. Jagger,Brett W. Jagger,Amanda D. Stuart,Zi H. Kang,Nicole C. Robb,Louis M. Schwartzman,John C. Kash,Ervin Fodor,Andrew E. Firth,Julia R. Gog,Jeffery K. Taubenberger,Paul Digard +13 more
TL;DR: In identifying a 14th influenza A polypeptide, the data reinforce the unexpectedly high coding capacity of the viral genome and have implications for virus evolution, as well as for understanding the role of M2 in the virus life cycle.
Journal ArticleDOI
A Rab11- and Microtubule-Dependent Mechanism for Cytoplasmic Transport of Influenza A Virus Viral RNA
Maria João Amorim,Emily A. Bruce,Eliot Read,Ágnes Foeglein,Robert Mahen,Amanda D. Stuart,Paul Digard +6 more
TL;DR: It is proposed that influenza virus RNPs are routed from the nucleus to the pericentriolar recycling endosome (RE), where they access a Rab11-dependent vesicular transport pathway to the cell periphery.