P
Paul Digard
Researcher at University of Edinburgh
Publications - 153
Citations - 15134
Paul Digard is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Influenza A virus & Virus. The author has an hindex of 53, co-authored 138 publications receiving 13670 citations. Previous affiliations of Paul Digard include University of Warwick & Harvard University.
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Journal ArticleDOI
The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection
Hannah Goldswain,Xiaofeng Dong,Rebekah Penrice-Randal,Muhannad Falah Alruwaili,Ghada Shawli,Tessa Prince,Maia Kavanagh Williamson,Jayna Raghwani,Nadine Randle,Benjamin Jones,I'ah Donovan-Banfield,Francisco J. Salguero,Julia A. Tree,Yper Hall,Catherine Hartley,Maximilian Erdmann,J.-M. Bazire,Tuksin Jearanaiwitayakul,Malcolm G Semple,J Kenneth Baillie,Peter J. M. Openshaw,Gail Carson,Beatrice Alex,Petros Andrikopoulos,Benjamin Bach,Wendy S. Barclay,Debby Bogaert,Meera Chand,Kanta Chechi,Graham S Cooke,Ana da Silva Filipe,Thushan I de Silva,Annemarie B Docherty,Gonçalo Dos Santos Correia,Marc-Emmanuel Dumas,Jake Dunning,Tom Fletcher,Chris Green,William Greenhalf,Julian L. Griffin,Rishi R. Gupta,Ewen M Harrison,Antonia Ho,Peter Horby,Samreen Ijaz,Saye Khoo,Paul Klenerman,Andy Law,Matthew R. Lewis,Sonia Liggi,Wei Shen Lim,Lyn Maslen,Alexander J. Mentzer,Laura Merson,Alison M. Meynert,Shona C Moore,Mahdad Noursadeghi,Michael Olanipekun,Anthonia Osagie,Massimo Palmarini,Carlo Palmieri,William A. Paxton,Georgios Pollakis,Nicholas C. Price,Andrew Rambaut,David Robertson,Clark D Russell,Vanessa Sancho-Shimizu,Caroline Sands,Janet T Scott,Louise Sigfrid,Tom Solomon,Shiranee Sriskandan,D. Stuart,C. Gail Summers,Olivia Swann,Zoltan Takats,Panteleimon G. Takis,Richard S. Tedder,Aaron Thompson,E. Thomson,Ryan S Thwaites,Lance Turtle,Maria Zambon,Hayley E Hardwick,Chloe Donohue,Fiona Griffiths,Wilna Oosthuyzen,Cara Donegan,Rebecca G Spencer,Lisa Norman,Riinu Pius,Thomas M Drake,Cameron J Fairfield,Stephen R Knight,Kenneth A. McLean,Derek Murphy,Catherine A Shaw,Joanne Dalton,Michelle Girvan,Eglė Savičiūtė,Stephanie Roberts,Janet Harrison,Laura Catherine Marsh,M Connor,Sophie Halpin,Clare Jackson,Carrol Gamble,Daniel Plotkin,James Lee,Gary Leeming,Murray Wham,Sara Clohisey,Ross Hendry,James Scott-Brown,Victoria Shaw,Seán Keating,K Alkamal Ahmed,Jane A Armstrong,Milton Ashworth,Innocent G Asiimwe,Siddharth Bakshi,Samantha L. Barlow,Laura Booth,Benjamin Brennan,Katie Bullock,Benjamin Catterall,Jordan J. Clark,Emily Clarke,Sarah Cole,Louise H. Cooper,Helen Cox,Christopher J. Davis,Oslem Dincarslan,Chris Dunn,Philip C. Dyer,Angela Elliott,Anthony Evans,L. Finch,L. Fisher,Terry Foster,Isabel García-Dorival,Philip John Gunning,Rebecca L Jensen,Christopher B. Jones,T. Jones,Shadia Khandaker,K. King,Robyn T. Kiy,Chrysa Koukorava,Annette Lake,Suzannah Lant,Diane Latawiec,L. Lavelle-Langham,Daniella A. Lefteri,Lauren Lett,Lucia A. Livoti,Maria Cecilia Mancini,Sarah E. McDonald,Laurence McEvoy,John M. McLauchlan,Soeren Metelmann,N. Miah,J. Middleton,Joyce Mitchell,Ellen G. Murphy,Jack Pilgrim,W Kirke Reynolds,Paul Ridley,Debby Sales,Rebecca K. Shears,Benjamin Small,Krishanthi Subramaniam,Agnieska Szemiel,Aislynn Taggart,Jolanta Tanianis-Hughes,Erwan Trochu,Libby Van Tonder,Evelyn Wilcock,J. E. Zhang,L Flaherty,Nicole Maziere,Emily Cass,A. Carracedo,N. A. Carlucci,Anthony Wayne Holmes,Hannah Massey,Lee Murphy,Sarah McCafferty,Richard Clark,Angie Fawkes,K.W. Morrice,Alan Maclean,Nicola Wrobel,Lorna Donnelly,Audrey Coutts,Katarzyna Hafezi,Louise MacGillivray,Tammy Gilchrist,K. Adeniji,Dan Agranoff,Kenneth N. Agwuh,Dhiraj Ail,Erin L. Aldera,Ana Maria Alegria,Sam Allen,B. Angus,Abdul Ashish,Doug Atkinson,S Bari,Gavin Barlow,S Barnass,Nicholas A Barrett,Christopher Bassford,S Basude,D. Baxter,Mike B.J. Beadsworth,Jolanta Bernatoniene,John Berridge,Colin Berry,Nicola G. Best,Pieter Bothma,David Chadwick,Robin Brittain-Long,Naomi S. Bulteel,Thomas G Burden,Andrew J. Burtenshaw,Vikki Caruth,D. Chambler,Nigel Chee,Jenny Child,Srikanth Chukkambotla,Tom S. Clark,Paul Collini,Catherine Cosgrove,Jason Cupitt,Maria Teresa Cutino-Moguel,Paul Dark,Christopher Peter Dawson,Samir Dervisevic,Phil Donnison,Sam Douthwaite,Andrew Robertson Newmarket Drummond,Ingrid Durand,Ahilanadan Dushianthan,Tristan Dyer,Cariad Evans,CU Eziefula,C. Fegan,Adam Finn,Duncan G. Fullerton,Sanjeev Garg,Atul Garg,Effrossyni Gkrania-Klotsas,Joy Godden,Arthur J. Goldsmith,Clive Graham,Elaine Hardy,Stuart Hartshorn,D. Harvey,Peter Havalda,Daniel B Hawcutt,M. Hobrok,L Hodgson,Anil Hormis,Michael Jacobs,Susan Jain,Paul Jennings,Agilan Kaliappan,V. Kasipandian,Stephen Legg,Michael R. Kelsey,Jason Kendall,C. Kerrison,Ian M. Kerslake,Oliver O Koch,Gouri Koduri,G. Koshy,Shondipon Laha,Steven P. Laird,Susan Larkin,Tamas Leiner,Patrick J. Lillie,James Limb,Vanessa Linnett,Jeff Little,M.T. Lyttle,Michael MacMahon,Emily Macnaughton,Ravish Mankregod,Huw Masson,Elijah Matovu,Katherine McCullough,Ruth McEwen,Manjula Meda,Gary H. Mills,Jane Minton,Mariyam Mirfenderesky,K. Mohandas,Quen Mok,James C. Moon,Eli K. Moore,Patrick Morgan,C. Morris,K. Mortimore,Samuel Rajan Moses,Mbiye A Mpenge,Rohinton Mulla,Michael J. Murphy,Megan Nagel,Thapas Nagarajan,Mark Nelson,L. Norris,Matthew K. O'Shea,Igor Otahal,Marlies Ostermann,M. Pais,S. Panchatsharam,Danai Papakonstantinou,Hassan Paraiso,Brij Patel,Natalie Pattison,Justin Pepperell,Mark J. Peters,Mandeep Phull,Stefania Pintus,J. Pooni,Tim Planche,F. Post,David Price,R. Aubrey Prout,Nikolas Rae,Henrik Reschreiter,Tim Reynolds,Neil Richardson,Mark S. Roberts,Devender Roberts,A. Rose,Guy Rousseau,Bobby Ruge,Brendan Ryan,T. Saluja,Matthias Schmid,Aarti Shah,Prad Shanmuga,Anil K. Sharma,A. Shawcross,J.P. Sizer,Manu Shankar-Hari,Richard D. Smith,Catherine M. Snelson,Nick Spittle,N. Staines,T. Stambach,R Stewart,P. Kissan Subudhi,Tamas Szakmany,Kate Tatham,Jordan Thomas,C. Thompson,Robert Thompson,Ascanio Tridente,Darell Alexander Tupper-Carey,Mary Twagira,Nick Vallotton,Rama Vancheeswaran,Lisbeth Vincent-Smith,Shico Visuvanathan,Alan Vuylsteke,Sam Waddy,Rachel M Wake,Andrew Stephen Walden,Ingeborg Welters,Tony Whitehouse,Paul Whittaker,Ashley M. Whittington,Padmasayee Papineni,Meme Wijesinghe,M. Williams,Lawrence W. Wilson,Stephen Winchester,Martin Wiselka,A. S. Wolverson,Daniel G. Wootton,Andrew J. Workman,Bryan Yates,Peter Young,Stevan R. Emmett,Paul Digard,David A. Matthews,Alistair C. Darby,Andrew D. Davidson,Miles W. Carroll,Julian A. Hiscox +393 more
TL;DR: In this article , the authors investigated the role of P323L/D614G substitutions in the emergence of SARS-CoV-2 variants in the COVID-19 pandemic.
Journal ArticleDOI
Heterogeneity of Early Host Response to Infection with Four Low-Pathogenic H7 Viruses with a Different Evolutionary History in the Field.
Gianpiero Zamperin,Alice Bianco,Jacqueline Smith,Alessio Bortolami,Lonneke Vervelde,Alessia Schivo,Andrea Fortin,Sabrina Marciano,Valentina Panzarin,Eva Mazzetto,Adelaide Milani,Yohannes Berhane,Paul Digard,Francesco Bonfante,Isabella Monne +14 more
TL;DR: In this paper, transcriptomic sequencing of tracheal tissue from chickens infected with four distinct LP H7 viruses, characterized by a different history of pathogenicity evolution in the field, was implemented.
Journal ArticleDOI
Comparison of the efficacy of a commercial inactivated influenza A/H1N1/pdm09 virus (pH1N1) vaccine and two experimental M2e-based vaccines against pH1N1 challenge in the growing pig model
Tanja Opriessnig,Tanja Opriessnig,Phillip C. Gauger,Priscilla F. Gerber,Alessandra Marnie Martins Gomes de Castro,Huigang Shen,Lita Murphy,Paul Digard,Patrick G. Halbur,Ming Xia,Xi Jiang,Ming Tan +11 more
TL;DR: A commercial Inact/pH1N1 specific vaccine effectively protected pigs against homologous challenge as evidenced by reduced clinical signs, virus shedding in nasal secretions and oral fluids and reduced macroscopic and microscopic lesions whereas intranasal vaccination with experimental M2e epitope-based subunit vaccines did not.
Posted ContentDOI
Comprehensive characterisation of molecular host-pathogen interactions in influenza A virus-infected human macrophages
Sara Clohisey,Nicholas J. Parkinson,Bo Wang,Nicolas Bertin,Helen M. Wise,Helen M. Wise,Andru Tomoiu,Kim M. Summers,Piero Carninci,Alistair Forrest,Yoshihide Hayashizaki,Paul Digard,David A. Hume,J Kenneth Baillie +13 more
TL;DR: Host gene expression reveals that human macrophages exposed to IAV exhibit sustained production of key inflammatory mediators and failure to induce expression of feedback inhibitors of inflammation, demonstrating that cap-snatching has a strong preference for, and aversion to, different groups of host transcripts.