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Paul Digard

Researcher at University of Edinburgh

Publications -  153
Citations -  15134

Paul Digard is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Influenza A virus & Virus. The author has an hindex of 53, co-authored 138 publications receiving 13670 citations. Previous affiliations of Paul Digard include University of Warwick & Harvard University.

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Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Daniel J. Klionsky, +2522 more
- 01 Jan 2016 - 
TL;DR: Author(s): Klionsky, DJ; Abdelmohsen, K; Abe, A; Abedin, MJ; Abeliovich, H; A Frozena, AA; Adachi, H, Adeli, K, Adhihetty, PJ; Adler, SG; Agam, G; Agarwal, R; Aghi, MK; Agnello, M; Agostinis, P; Aguilar, PV; Aguirre-Ghis
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Polymerization activity of an alpha-like DNA polymerase requires a conserved 3'-5' exonuclease active site

TL;DR: The results raise the possibility that there is a fundamental difference betweenalpha-like DNA polymerases and E. coli DNA polymerase I, with less distinction between 3'-5' exonuclease and polymerase functions in alpha-likeDNA polymerases.
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The influence of viral coding sequences on pestivirus IRES activity reveals further parallels with translation initiation in prokaryotes

TL;DR: It is shown here that CSFV has an exceptionally efficient cis-acting internal ribosome entry segment (IRES), which, like that of HCV, is strongly influenced by the sequences immediately downstream of the initiation codon, and is optimal with viral coding sequences in this position.
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Influenza — Time to Target the Host?

TL;DR: A search for an endogenous lipid mediator of influenza virus resistance identified protectin D1, a molecule that regulates transport of RNA from the nucleus, which prevented death in mice exposed to influenza A.
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Increased amounts of the influenza virus nucleoprotein do not promote higher levels of viral genome replication.

TL;DR: In a plasmid-based system for reconstituting active viral RNPs in cells, titration of increasing amounts of NP did not promote higher levels of genome replication relative to transcription, but rather caused the opposite effect.