M
Maria João Amorim
Researcher at Instituto Gulbenkian de Ciência
Publications - 59
Citations - 2982
Maria João Amorim is an academic researcher from Instituto Gulbenkian de Ciência. The author has contributed to research in topics: Influenza A virus & Ribonucleoprotein. The author has an hindex of 21, co-authored 52 publications receiving 2246 citations. Previous affiliations of Maria João Amorim include University of Chicago & University of Pennsylvania.
Papers
More filters
Journal ArticleDOI
Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells.
Angela Colmone,Maria João Amorim,Andrea Pontier,Sheng Wang,Elizabeth M. Jablonski,Dorothy A. Sipkins +5 more
TL;DR: It is suggested that the tumor microenvironment causes HPC dysfunction by usurping normal HPC niches and that therapeutic inhibition of HPC interaction with tumor niches may help maintain normal progenitor cell function in the setting of malignancy.
Journal ArticleDOI
Technical challenges of working with extracellular vesicles
Marcel I. Ramirez,Marcel I. Ramirez,Maria João Amorim,Catarina Gadelha,Ivana Milic,Joshua A. Welsh,Vanessa de Moraes Freitas,Muhammad Nawaz,Muhammad Nawaz,Naveed Akbar,Yvonne Couch,Laura Makin,Fiona G. M. Cooke,André Luiz Vettore,Patricia X. Batista,Roberta Freezor,Julia Alejandra Pezuk,Livia Rosa-Fernandes,Livia Rosa-Fernandes,Ana Claudia Oliveira Carreira,Andrew Devitt,Laura Jacobs,Israel Tojal da Silva,Gillian Coakley,Diana N. Nunes,Dave Carter,Giuseppe Palmisano,Emmanuel Dias-Neto +27 more
TL;DR: Small sizes and the limited quantities that can usually be obtained from patient-derived samples pose a number of challenges to their isolation, study and characterization, which are discussed in this review.
Journal ArticleDOI
Exosome Biogenesis, Regulation, and Function in Viral Infection.
Marta Alenquer,Maria João Amorim +1 more
TL;DR: This review focuses on the composition and biogenesis of exosomes, and explores the regulatory mechanisms underlying their biogenesis, and how different viruses exploit specific proteins of endocytic sub-compartments to exploit exosome function.
Journal ArticleDOI
Rett syndrome mutation MeCP2 T158A disrupts DNA binding, protein stability and ERP responses
Darren Goffin,Megan Allen,Le Zhang,Maria João Amorim,I-Ting Judy Wang,Arith-Ruth S. Reyes,Amy Mercado-Berton,Caroline Ong,Sonia Cohen,Linda Hu,Julie A. Blendy,Gregory C. Carlson,Steve J. Siegel,Michael E. Greenberg,Zhaolan Zhou +14 more
TL;DR: The age-dependent development of event-related neuronal responses was disrupted by MeCP2 mutation, suggesting that impaired neuronal circuitry underlies the pathogenesis of RTT and that assessment of event the-related potentials (ERPs) may serve as a biomarker for RTt and treatment evaluation.
Journal ArticleDOI
A Rab11- and Microtubule-Dependent Mechanism for Cytoplasmic Transport of Influenza A Virus Viral RNA
Maria João Amorim,Emily A. Bruce,Eliot Read,Ágnes Foeglein,Robert Mahen,Amanda D. Stuart,Paul Digard +6 more
TL;DR: It is proposed that influenza virus RNPs are routed from the nucleus to the pericentriolar recycling endosome (RE), where they access a Rab11-dependent vesicular transport pathway to the cell periphery.