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Patricia A. Taylor
Researcher at University of Minnesota
Publications - 144
Citations - 12422
Patricia A. Taylor is an academic researcher from University of Minnesota. The author has contributed to research in topics: Graft-versus-host disease & T cell. The author has an hindex of 61, co-authored 136 publications receiving 11371 citations. Previous affiliations of Patricia A. Taylor include University of Michigan & University of Iowa.
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Journal ArticleDOI
The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality.
TL;DR: This study is the first to demonstrate that activated, cultured CD4(+)CD25(+) cells can offer substantial protection in a relevant in vivo animal model of disease and have important ramifications for clinical bone marrow and solid organ transplantation.
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Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis
Teruaki Nakatsuji,Tiffany H. Chen,Saisindhu Narala,Kimberly A. Chun,Aimee M. Two,Tong Yun,Faiza Shafiq,Paul Kotol,Amina Bouslimani,Alexey V. Melnik,Haythem Latif,Ji-Nu Kim,Alexandre Lockhart,Keli Artis,Gloria David,Patricia A. Taylor,Joanne E. Streib,Pieter C. Dorrestein,Pieter C. Dorrestein,Alex Grier,Steven R. Gill,Karsten Zengler,Tissa Hata,Donald Y.M. Leung,Richard L. Gallo +24 more
TL;DR: Reintroduction of antimicrobial CoNS strains to human subjects with AD decreased colonization by S. aureus, showing how commensal skin bacteria protect against pathogens and how dysbiosis of the skin microbiome can lead to disease.
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Cd4+Cd25+ Immune Regulatory Cells Are Required for Induction of Tolerance to Alloantigen via Costimulatory Blockade
TL;DR: Data are the first to indicate that CD4+CD25+ cells are essential for the induction of tolerance to alloantigen and have important implications for tolerance-inducing strategies targeted at T cell costimulatory pathways.
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Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13.
Steven L. Highfill,Paulo C. Rodriguez,Qing Zhou,Christine A. Goetz,Brent H. Koehn,Rachelle G. Veenstra,Patricia A. Taylor,Angela Panoskaltsis-Mortari,Jonathan S. Serody,David H. Munn,Jakub Tolar,Augusto C. Ochoa,Bruce R. Blazar +12 more
TL;DR: MDSC-IL-13 and pegylated form of human arginase-1 represent novel strategies to prevent GVHD that can be clinically translated.
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L-Selectinhi but not the L-selectinlo CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection
Patricia A. Taylor,Angela Panoskaltsis-Mortari,Jessica M. Swedin,Philip J. Lucas,Ronald E. Gress,Bruce L. Levine,Carl H. June,Jonathan S. Serody,Bruce R. Blazar +8 more
TL;DR: In this paper, a direct comparison of LSEL(hi) and LSel(lo) Tregs for GVHD inhibition and for the promotion of allogeneic BM engraftment was provided.