Paul M. Brickell

TL;DR: It is shown here that bone morphogenetic protein 2 (BMP-2) is involved in patterning the developing chick limb and there is a close relationship, both temporal and spatial, between the activation of the Bmp-2 and Hoxd-13 genes in response to retinoic acid and polarizing region grafts, suggesting that expression of the two genes might be linked.

TL;DR: This work reports the identification of a specific marker for the lateral somitic compartment and its early derivatives, cSim1, an avian homolog of the Drosophila single minded gene, and implicates bone morphogenetic protein 4(BMP4) in directing this lateralization.

TL;DR: Insight is provided into how BMP-2 and B MP-4 may model and control the growth of skeletal elements during normal embryonic development, suggesting roles for both molecules in recruiting non-chondrogenic precursors to chondrogenics fate.

TL;DR: Data suggest that Cdc42‐WASp‐mediated filopodial extension is a requirement for chemotaxis but not for chemokinesis in these cells, and supports the existence of an essential functional link between CDC42, WAS protein (WASP) and the actin cytoskeleton in primary human macrophages.

TL;DR: It is shown that Fcgamma-receptor-mediated phagocytosis is impaired in WASp-deficient peripheral blood monocytes, and that in macrophages, formation of the actin cup and local recruitment of tyrosine phosphorylated proteins is markedly attenuated.