Paul Matsudaira

TL;DR: Small amounts of myoglobin, beta-lactoglobulin, and other proteins and peptides can be spotted or electroblotted onto polyvinylidene difluoride membranes, stained with Coomassie Blue, and sequenced directly, suggesting that PVDF membranes are superior supports for sequence analysis of picomole quantities of proteins purified by gel electrophoresis.

TL;DR: The experimental findings here represent, to the knowledge, discovery of a previously undescribed set of balances of cell and matrix properties that govern the ability of tumor cells to migration in 3D environments.

TL;DR: It is shown that networks of cross-linked and bundled actin filaments exhibit exceptional elastic behavior that reflects the mechanical properties of individual filaments, and parameterize the full range of behavior in a state diagram and elucidate its origin with a robust model.

TL;DR: The trimeric structure of the bovine type I scavenger receptor contains three extracellular C-terminal cysteine-rich domains connected to the transmembrane domain by a long fibrous stalk.

TL;DR: It is shown that 3- and 4-kDa peptides derived from amyloid precursor protein are normally secreted and evidence that glial cells are a major source of beta-amyloid production in the brain is provided.