Paul Matsudaira

TL;DR: The combined advances, particularly those in read length and sample requirement, directly address the cost model requirements for adaptation of the new technology as the next step beyond capillary array instruments.

TL;DR: In this paper, the authors tracked gold nanoparticles moving in water at the liquid-solid interface with in situ TEM at rates of 100 frames per second, and the recorded motion exhibited three key features: (1) sustained sequences of sticky motion where NPs only moved a few nanometers each time; (2) sporadic long "flights" where the NPs traveled tens to hundreds of nanometers between frames; and (3) “flights” are accompanied by intermittent, fast pivoted rotations.

TL;DR: It is suggested that the F‐actin binding domains of actin severing, crosslinking and capping proteins can be organized into two classes: headpiece and V2‐3, which form the two cross‐linking sites of villin.

TL;DR: DNA fragment biasing was reduced significantly through the unique sample injection mechanism of the microfabricated device, which led to increased signal strength for long fragments, which is of great importance for the high performance of themicrodevice.

TL;DR: Results indicate that the actin:scruin composite bundle has an average elastic modulus of 2 GPa, which is similar to that of a single actin filament, and a bending stiffness that is more than two orders of magnitude larger than a bundle of uncross-linked actin filaments due to stiffening by the scruin matrix.