P
Paul R. Blakemore
Researcher at Oregon State University
Publications - 83
Citations - 2666
Paul R. Blakemore is an academic researcher from Oregon State University. The author has contributed to research in topics: Julia olefination & Reagent. The author has an hindex of 22, co-authored 81 publications receiving 2431 citations. Previous affiliations of Paul R. Blakemore include University of Leeds & Eli Lilly and Company.
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A Stereoselective Synthesis of trans-1,2-Disubstituted Alkenes Based on the Condensation of Aldehydes with Metallated 1-Phenyl-1H-tetrazol-5-yl Sulfones
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The modified Julia olefination: alkene synthesis via the condensation of metallated heteroarylalkylsulfones with carbonyl compounds
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Iterative Stereospecific Reagent-Controlled Homologation of Pinacol Boronates by Enantioenriched α-Chloroalkyllithium Reagents
TL;DR: In this paper, the reaction of pinacol boronates with putative enantioenriched α-chloroalkyllithium species, generated in situ from homochiral αchloroalkylsulfoxides by sulfoxide ligand exchange with t-BuLi in PhMe at −78 °C, gave chain-extended boronic ester products with generally excellent stereochemical fidelity.
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Morphine, the Proteus of organic molecules
Paul R. Blakemore,James D. White +1 more
TL;DR: This feature article encapsulates the senior author's longstanding interests in opiate chemistry and attempts to place it within an historical context and against the backdrop of related work by others who have viewed morphine as one of the pinnacles of natural product synthesis.
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Reagent-controlled asymmetric homologation of boronic esters by enantioenriched main-group chiral carbenoids.
TL;DR: Alcohols derived from the product boronates by oxidation with basic hydrogen peroxide exhibited % ee closely approaching that of sulfoxide 8 in examples employing Li-carbenoid 26.