D
Douglas E. Berg
Researcher at University of California, San Diego
Publications - 276
Citations - 24156
Douglas E. Berg is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Helicobacter pylori & Transposable element. The author has an hindex of 73, co-authored 275 publications receiving 23202 citations. Previous affiliations of Douglas E. Berg include University of Tokyo & University of Wisconsin-Madison.
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Journal ArticleDOI
The complete genome sequence of the gastric pathogen Helicobacter pylori
Jean-F. Tomb,Owen White,Anthony R. Kerlavage,Rebecca A. Clayton,Granger G. Sutton,Robert D. Fleischmann,Karen A. Ketchum,Hans-Peter Klenk,Steven R. Gill,Brian Dougherty,Karen E. Nelson,John Quackenbush,Lixin Zhou,Ewen F. Kirkness,Scott N. Peterson,Brendan J. Loftus,Delwood Richardson,Robert J. Dodson,Hanif Khalak,Anna Glodek,Keith McKenney,Lisa M. Fitzegerald,Norman H. Lee,Mark Raymond Adams,Erin Hickey,Douglas E. Berg,Jeanine D. Gocayne,Teresa Utterback,Jeremy Peterson,Jenny M. Kelley,Matthew D. Cotton,J. Weidman,Claire Fujii,Cheryl Bowman,Larry Watthey,Erik Wallin,William S. Hayes,Mark Borodovsky,Peter D. Karp,Hamilton O. Smith,Claire M. Fraser,J. Craig Venter +41 more
TL;DR: Sequence analysis indicates that H. pylori has well-developed systems for motility, for scavenging iron, and for DNA restriction and modification, and consistent with its restricted niche, it has a few regulatory networks, and a limited metabolic repertoire and biosynthetic capacity.
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Helicobacter pylori Adhesin Binding Fucosylated Histo-Blood Group Antigens Revealed by Retagging
Dag Ilver,Anna Arnqvist,Johan Ögren,Inga-Maria Frick,Dangeruta Kersulyte,Engin T. Incecik,Douglas E. Berg,Antonello Covacci,Lars Engstrand,Thomas Borén +9 more
TL;DR: The bacterial Leb-binding phenotype was associated with the presence of the cag pathogenicity island among clinical isolates of H. pylori, suggesting that a vaccine strategy based on the BabA adhesin might serve as a means to target the virulent type I strains of the bacterium.
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Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation.
Jafar Mahdavi,Berit Sondén,Martina Hurtig,Farzad O. Olfat,Farzad O. Olfat,Lina Forsberg,Niamh Roche,Jonas Ångström,Thomas Larsson,Susann Teneberg,Karl-Anders Karlsson,Siiri Altraja,Torkel Wadström,Dangeruta Kersulyte,Douglas E. Berg,Andre Dubois,Christoffer Petersson,Karl-Eric Magnusson,Thomas Norberg,Frank Lindh,Bertil Lundskog,Anna Arnqvist,Lennart Hammarström,Thomas Borén +23 more
TL;DR: The ability of many H. pylori strains to adhere to sialylated glycoconjugates expressed during chronic inflammation might contribute to virulence and the extraordinary chronicity ofH.pylori infection.
Journal ArticleDOI
DNA diversity among clinical isolates of Helicobacter pylori detected by PCR-based RAPD fingerprinting
TL;DR: The RAPD (or AP-PCR) DNA fingerprinting method was used to distinguish among clinical isolates of Helicobacter pylori, a bacterium whose long term carriage is associated with gastritis, peptic ulcers and gastric carcinomas.
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Culture Independent Analysis of Ileal Mucosa Reveals a Selective Increase in Invasive Escherichia Coli of Novel Phylogeny Relative to Depletion of Clostridiales in Crohn's Disease Involving the Ileum
Martin Baumgart,Belgin Dogan,Mark Rishniw,Gil Weitzman,Brian P. Bosworth,Rhonda K. Yantiss,Renato H. Orsi,Martin Wiedmann,Patrick L. McDonough,Sung Guk Kim,Douglas E. Berg,Ynte H. Schukken,Ellen Scherl,Kenneth W. Simpson +13 more
TL;DR: It is established that dysbiosis of the ileal mucosa-associated flora correlates with an ILEal Crohn's disease (ICD) phenotype, and the possibility that a selective increase in a novel group of invasive E. coli is involved in the etiopathogenesis to Crohn’s disease involving the ilesum is raised.