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Paul S. Knoepfler
Researcher at University of California, Davis
Publications - 105
Citations - 7026
Paul S. Knoepfler is an academic researcher from University of California, Davis. The author has contributed to research in topics: Induced pluripotent stem cell & Stem cell. The author has an hindex of 44, co-authored 101 publications receiving 6571 citations. Previous affiliations of Paul S. Knoepfler include Fred Hutchinson Cancer Research Center & Shriners Hospitals for Children.
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N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation.
TL;DR: N-myc is essential for normal neurogenesis, regulating NPC proliferation, differentiation, and nuclear size, and its effects on proliferation and differentiation appear due, at least in part, to down-regulation of a specific subset of cyclin-dependent kinase inhibitors.
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Deconstructing Stem Cell Tumorigenicity: A Roadmap to Safe Regenerative Medicine
TL;DR: The links between pluripotency and tumorigenicity are explored and IPSC are predicted to possess tumorigenic potential equal to or greater than that of ESC, perhaps the most promising modality for future patient‐specific regenerative medicine therapies.
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Sin meets NuRD and other tails of repression
TL;DR: A profound connection between transcriptional repression and fundamental aspects of cell biology including proliferation, differentiation, and cancer is illuminated and different corepressors may be thought of as acting to unleash HDAC activities at the target site in distinct ways.
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Myc influences global chromatin structure.
Paul S. Knoepfler,Xiao-yong Zhang,Pei Feng Cheng,Philip R. Gafken,Steven B. McMahon,Robert N. Eisenman +5 more
TL;DR: This study provides the first evidence for regulation of global chromatin structure by an oncoprotein and may explain the broad effects of Myc on cell behavior and tumorigenesis.
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Pbx marks genes for activation by MyoD indicating a role for a homeodomain protein in establishing myogenic potential.
Charlotte A. Berkes,Donald A. Bergstrom,Donald A. Bergstrom,Bennett H. Penn,Karen J. Seaver,Paul S. Knoepfler,Stephen J. Tapscott +6 more
TL;DR: It is shown that the H/C and helix III domains, two domains of MyoD that are necessary for the initiation of chromatin remodeling at the myogenin locus, together regulate a restricted subset of genes, including myogenIn, which reveals a critical role of homeodomain proteins in marking specific genes for activation in the muscle lineage.