P
Paula Alejandra Sacca
Researcher at University of Buenos Aires
Publications - 10
Citations - 299
Paula Alejandra Sacca is an academic researcher from University of Buenos Aires. The author has contributed to research in topics: Prostate cancer & Cell growth. The author has an hindex of 6, co-authored 9 publications receiving 274 citations. Previous affiliations of Paula Alejandra Sacca include Facultad de Ciencias Exactas y Naturales.
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Journal ArticleDOI
A unique galectin signature in human prostate cancer progression suggests galectin-1 as a key target for treatment of advanced disease
Diego Jose Laderach,Lucas Daniel Gentilini,Laura Giribaldi,Víctor M. Cárdenas Delgado,Lorena G. Nugnes,Diego O. Croci,Nader Al Nakouzi,Paula Alejandra Sacca,Gabriel Casas,Osvaldo Mazza,Margaret A. Shipp,Elba Vazquez,Anne Chauchereau,Jeffery L. Kutok,Scott J. Rodig,María T. Elola,Daniel Compagno,Gabriel A. Rabinovich +17 more
TL;DR: A dynamically regulated "galectin-specific signature" that accompanies disease evolution in prostate cancer is identified and highlighted, highlighting a major role for Gal-1 as a tractable target for antiangiogenic therapy in advanced stages of the disease.
Journal ArticleDOI
ALA and ALA hexyl ester in free and liposomal formulations for the photosensitisation of tumour organ cultures.
Adriana Casas,Christian Perotti,M Saccoliti,Paula Alejandra Sacca,Haydée Fukuda,A M del C Batlle +5 more
TL;DR: It was demonstrated that exposure of tumour explants to either free or liposomal 5-aminolevulinic acid and subsequent illumination induces the same type of subcellullar damage.
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ALA and ALA hexyl ester induction of porphyrins after their systemic administration to tumour bearing mice.
TL;DR: In most normal tissues as well as in tumour, He-ALA induced less porphyrin synthesis than ALA after its systemic administration either intravenous or intraperitoneal, although explant organ cultures exposed to either ALA or He- ALA revealed equally active esterases.
Journal ArticleDOI
Adipocyte differentiation influences the proliferation and migration of normal and tumoral breast epithelial cells
Virginia Pistone Creydt,Paula Alejandra Sacca,Amelia Julieta Tesone,Luciano Vidal,Juan Carlos Calvo +4 more
TL;DR: In conclusion, adipocyte differentiation influences normal and tumoral breast epithelial cell proliferation and migration and Heparanase and MMP-9 appear to be involved in this regulation.
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Topical application of ALA and ALA hexyl ester on a subcutaneous murine mammary adenocarcinoma: tissue distribution.
TL;DR: This work employed a subcutaneous murine mammary adenocarcinoma to study the tissue distribution pattern of the ALA hexyl ester (He-ALA) in comparison with ALA after their topical application in different vehicles, reinforcing the importance of the vehicle in the use of topical PDT.