L
Lucas Daniel Gentilini
Researcher at Facultad de Ciencias Exactas y Naturales
Publications - 15
Citations - 467
Lucas Daniel Gentilini is an academic researcher from Facultad de Ciencias Exactas y Naturales. The author has contributed to research in topics: Prostate cancer & Galectin. The author has an hindex of 10, co-authored 14 publications receiving 395 citations. Previous affiliations of Lucas Daniel Gentilini include University of Buenos Aires.
Papers
More filters
Journal ArticleDOI
A unique galectin signature in human prostate cancer progression suggests galectin-1 as a key target for treatment of advanced disease
Diego Jose Laderach,Lucas Daniel Gentilini,Laura Giribaldi,Víctor M. Cárdenas Delgado,Lorena G. Nugnes,Diego O. Croci,Nader Al Nakouzi,Paula Alejandra Sacca,Gabriel Casas,Osvaldo Mazza,Margaret A. Shipp,Elba Vazquez,Anne Chauchereau,Jeffery L. Kutok,Scott J. Rodig,María T. Elola,Daniel Compagno,Gabriel A. Rabinovich +17 more
TL;DR: A dynamically regulated "galectin-specific signature" that accompanies disease evolution in prostate cancer is identified and highlighted, highlighting a major role for Gal-1 as a tractable target for antiangiogenic therapy in advanced stages of the disease.
Journal ArticleDOI
Galectin-1 triggers epithelial-mesenchymal transition in human hepatocellular carcinoma cells.
María L. Bacigalupo,Malena Manzi,María V. Espelt,Lucas Daniel Gentilini,Daniel Compagno,Diego Jose Laderach,Carlota Wolfenstein-Todel,Gabriel A. Rabinovich,María F. Troncoso +8 more
TL;DR: Extensive Gal1 expression facilitated the transition from epithelial cell morphology towards a fibroblastoid phenotype and favored up‐regulation of the mesenchymal marker vimentin in HCC cells, with critical implications in H CC metastasis.
Journal ArticleDOI
Galectin-8: a matricellular lectin with key roles in angiogenesis.
María F. Troncoso,Fátima Ferragut,María L. Bacigalupo,Víctor M. Cárdenas Delgado,Lorena G. Nugnes,Lucas Daniel Gentilini,Diego Jose Laderach,Carlota Wolfenstein-Todel,Daniel Compagno,Gabriel A. Rabinovich,María T. Elola +10 more
TL;DR: A novel role for gal-8 is described in the regulation of vascular and lymphatic angiogenesis and evidence of its critical implications in tumor biology is provided, including cell adhesion and migration, which collectively demonstrate the multi-functionality of this complex lectin.
Journal ArticleDOI
Galectins: major signaling modulators inside and outside the cell.
Daniel Compagno,Felipe Martín Jaworski,Lucas Daniel Gentilini,Geraldine Contrufo,I. Gonzalez Perez,María T. Elola,N. Pregi,Gabriel A. Rabinovich,Diego Jose Laderach +8 more
TL;DR: This review summarizes the current knowledge of the signaling pathways activated by galectins, their glycan dependence and the cellular compartment where they become activated and are biologically relevant.
Journal ArticleDOI
Glycans and galectins in prostate cancer biology, angiogenesis and metastasis
Daniel Compagno,Lucas Daniel Gentilini,Felipe Martín Jaworski,Ignacio Gonzales Perez,Geraldine Contrufo,Diego Jose Laderach +5 more
TL;DR: Current evidence on both the expression and role of glycans and galectins in prostate cancer is summarized, particularly turning the authors' attention to the angiogenic and metastatic processes.