Journal ArticleDOI
Comparison of digital rectal examination and serum prostate specific antigen in the early detection of prostate cancer: results of a multicenter clinical trial of 6,630 men.
William J. Catalona,Jerome P. Richie,Frederick R. Ahmann,M'Liss A. Hudson,Peter T. Scardino,Robert C. Flanigan,Jean B. deKernion,Timothy L. Ratliff,Louis R. Kavoussi,Bruce L. Dalkin,W. Bedford Waters,Michael T. Macfarlane,Paula C. Southwick +12 more
TLDR
In this paper, a prospective clinical trial at 6 university centers of 6,630 male volunteers 50 years old or older who underwent PSA determination (Hybritech Tandom-E or Tandem-R assays) and digital rectal examination was conducted.About:
This article is published in The Journal of Urology.The article was published on 1994-05-01. It has received 1305 citations till now. The article focuses on the topics: Transrectal ultrasonography & Rectal examination.read more
Citations
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Journal ArticleDOI
Clinical practice guidelines in oncology
William J. Gradishar,Benjamin O. Anderson,Ron Balassanian,Sarah L. Blair,Harold J. Burstein,Amy E. Cyr,Anthony D. Elias,William B. Farrar,Andres Forero,Sharon H. Giordano,Matthew P. Goetz,Lori J. Goldstein,Steven J. Isakoff,Janice A. Lyons,P. Kelly Marcom,Ingrid A. Mayer,Beryl McCormick,Meena S. Moran,Ruth O'Regan,Sameer A. Patel,Lori J. Pierce,Elizabeth C. Reed,Kilian E. Salerno,Lee S. Schwartzberg,Amy Sitapati,Karen L. Smith,Mary Lou Smith,Hatem Soliman,George Somlo,Melinda L. Telli,John H. Ward,Rashmi Kumar,Dorothy A. Shead +32 more
TL;DR: This manuscript focuses on the NCCN Guidelines Panel recommendations for the workup, primary treatment, risk reduction strategies, and surveillance specific to DCIS.
Journal ArticleDOI
International Variation in Prostate Cancer Incidence and Mortality Rates
Ahmedin Jemal,Joannie Lortet-Tieulent,Elizabeth Ward,Jacques Ferlay,Otis W. Brawley,Freddie Bray +5 more
TL;DR: PCa incidence rates increased in nearly all countries considered in this analysis except in a few high-income countries, and the increase in PCa mortality rates mainly occurred in lower resource settings, with declines largely confined to high-resource countries.
Journal ArticleDOI
Use of the Percentage of Free Prostate-Specific Antigen to Enhance Differentiation of Prostate Cancer From Benign Prostatic Disease: A Prospective Multicenter Clinical Trial
William J. Catalona,Alan W. Partin,Kevin M. Slawin,Michael K. Brawer,Robert C. Flanigan,Anup Patel,Jerome P. Richie,Jean B. deKernion,Patrick C. Walsh,Peter T. Scardino,Paul H. Lange,Eric N.P. Subong,Robert E. Parson,Gail H. Gasior,Kathleen G. Loveland,Paula C. Southwick +15 more
TL;DR: Use of the percentage of free PSA can reduce unnecessary biopsies in patients undergoing evaluation for prostate cancer, with a minimal loss in sensitivity in detecting cancer.
Guidelines on Prostate Cancer
Axel Heidenreich,Joaquim Bellmunt,Michel Bolla,Steven Joniau,Vsevolod Matveev,N. Mottet,Thomas Wiegel,Filiberto Zattoni +7 more
TL;DR: The introduction of an effective blood test, prostate specific antigen (PSA), has made it possible to diagnose more and more men in an earlier stage where they can be offered potentially curative treatments, and this is the subject of the EAU guidelines on prostate cancer.
Journal ArticleDOI
Prostate cancer detection in men with serum PSA concentrations of 2.6 to 4.0 ng/mL and benign prostate examination. Enhancement of specificity with free PSA measurements.
TL;DR: Using a percentage of free PSA cutoff of 27% or less as a criterion for performing prostatic biopsy would have detected 90% of cancers, avoided 18% of benign biopsies, and yielded a positive predictive value of 24% in men who underwent biopsy.
References
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Journal ArticleDOI
Measurement of prostate-specific antigen in serum as a screening test for prostate cancer.
William J. Catalona,Deborah S. Smith,Timothy L. Ratliff,Kathy M. Dodds,Douglas E. Coplen,Jerry J.J. Yuan,John A. Petros,Gerald L. Andriole +7 more
TL;DR: The combination of measurement of the serum PSA concentration and rectal examination, with ultrasonography performed in patients with abnormal findings, provides a better method of detecting prostate cancer thanrectal examination alone.
Journal ArticleDOI
Prostate-Specific Antigen as a Serum Marker for Adenocarcinoma of the Prostate
TL;DR: PSA is more sensitive than PAP in the detection of prostatic cancer and will probably be more useful in monitoring responses and recurrence after therapy, however, since both PSA and PAP may be elevated in benign prostatic hyperplasia, neither marker is specific.
Journal ArticleDOI
A controlled trial of leuprolide with and without flutamide in prostatic carcinoma.
E. D. Crawford,Mario A. Eisenberger,David G. McLeod,J T Spaulding,Ralph C. Benson,F A Dorr,Brent A. Blumenstein,M A Davis,P J Goodman +8 more
TL;DR: Treatment with le uprolide and flutamide is superior to treatment with leuprolide alone in patients with advanced prostate cancer, and Symptomatic improvement was greatest during the first 12 weeks of the combined androgen blockade.
Journal ArticleDOI
Longitudinal evaluation of prostate-specific antigen levels in men with and without prostate disease.
H. Ballentine Carter,Jay D. Pearson,E. Jeffrey Metter,Larry J. Brant,Larry J. Brant,Daniel W. Chan,Reubin Andres,Reubin Andres,James L. Fozard,Patrick C. Walsh +9 more
TL;DR: The most significant factor affecting serum PSA levels with age is the development of prostate disease, and rate of change in PSALevels may be a sensitive and specific early clinical marker for theDevelopment of prostate cancer.
Journal ArticleDOI
Detection of organ-confined prostate cancer is increased through prostate-specific antigen-based screening.
TL;DR: Screening based on PSA identifies some men with prostate cancer who have a significantly increased proportion of organ-confined tumors compared with those detected through evaluation for an abnormal digital rectal examination alone.