Paula L. Roesch

TL;DR: The complete genome sequence of uropathogenic Escherichia coli, strain CFT073 is presented and Comparisons indicate that extraintestinal pathogenic E. coli arose independently from multiple clonal lineages.

TL;DR: Results indicate that ipuA has fimB-like on-to-off and off- to-on fim switching activity and that ipbA has the ability to switch fim from the off to the on orientation.

TL;DR: A role for d-serine catabolism and signaling in global virulence gene regulation of uropathogenic E. coli strain CFT073 results in a hypermotile strain with a hypercolonization phenotype in the bladder and kidneys of mice in a model of urinary tract infection (UTI).

TL;DR: In a direct competition model of urinary tract infection, the dsdA mutant was recovered 300‐times more frequently than the wild type in the bladders of mice 48 h after infection, suggesting that d‐serine catabolism provides a growth advantage in the urinary tract.

TL;DR: Haugen et al. as mentioned in this paper showed that deletion of the genes encoding l-serine deaminases SdaA and SdaB resulted in a mutant that accumulates higher intracellular levels of lserine than CFT073.