N
Nicole T. Perna
Researcher at University of Wisconsin-Madison
Publications - 81
Citations - 26576
Nicole T. Perna is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 45, co-authored 81 publications receiving 24306 citations. Previous affiliations of Nicole T. Perna include Wisconsin Alumni Research Foundation & University of California, San Diego.
Papers
More filters
Journal ArticleDOI
The Complete Genome Sequence of Escherichia coli K-12
Frederick R. Blattner,Guy Plunkett,Craig A. Bloch,Nicole T. Perna,Valerie Burland,Monica Riley,Julio Collado-Vides,Jeremy D. Glasner,Christopher K. Rode,George F. Mayhew,Jason Gregor,Nelson Wayne Davis,Heather A. Kirkpatrick,Michael A. Goeden,Debra J. Rose,Bob Mau,Ying Shao +16 more
TL;DR: The 4,639,221-base pair sequence of Escherichia coli K-12 is presented and reveals ubiquitous as well as narrowly distributed gene families; many families of similar genes within E. coli are also evident.
Journal ArticleDOI
Mauve: multiple alignment of conserved genomic sequence with rearrangements.
TL;DR: This work presents methods for identification and alignment of conserved genomic DNA in the presence of rearrangements and horizontal transfer and evaluated the quality of Mauve alignments and drawn comparison to other methods through extensive simulations of genome evolution.
Journal ArticleDOI
progressiveMauve: Multiple Genome Alignment with Gene Gain, Loss and Rearrangement
TL;DR: A new method to align two or more genomes that have undergone rearrangements due to recombination and substantial amounts of segmental gain and loss is described, demonstrating high accuracy in situations where genomes have undergone biologically feasible amounts of genome rearrangement, segmental loss and loss.
Journal ArticleDOI
Genome sequence of enterohaemorrhagic Escherichia coli O157:H7
Nicole T. Perna,Guy Plunkett,Valerie Burland,Bob Mau,Jeremy D. Glasner,Debra J. Rose,George F. Mayhew,Peter Evans,Jason Gregor,Heather A. Kirkpatrick,György Pósfai,Jeremiah D. Hackett,Sara A. Klink,Adam T. Boutin,Ying Shao,Leslie Miller,Erik J. Grotbeck,N. Wayne Davis,Alex Lim,Eileen T. Dimalanta,Konstantinos Potamousis,Jennifer Apodaca,Thomas Anantharaman,Jieyi Lin,Galex Yen,David C. Schwartz,Rodney A. Welch,Frederick R. Blattner +27 more
TL;DR: It is found that lateral gene transfer is far more extensive than previously anticipated and 1,387 new genes encoded in strain-specific clusters of diverse sizes were found in O157:H7, including candidate virulence factors, alternative metabolic capacities, several prophages and other new functions—all of which could be targets for surveillance.
Journal ArticleDOI
Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli
Rodney A. Welch,Valerie Burland,Guy Plunkett,Peter Redford,Paula L. Roesch,David A. Rasko,Eric L. Buckles,S. R. Liou,S. R. Liou,Adam T. Boutin,Adam T. Boutin,Jeremiah D. Hackett,Jeremiah D. Hackett,D. Stroud,George F. Mayhew,Debra J. Rose,Shiguo Zhou,David C. Schwartz,Nicole T. Perna,Harry L. T. Mobley,Michael S. Donnenberg,Frederick R. Blattner +21 more
TL;DR: The complete genome sequence of uropathogenic Escherichia coli, strain CFT073 is presented and Comparisons indicate that extraintestinal pathogenic E. coli arose independently from multiple clonal lineages.