Paula Soler-Vila

TL;DR: In this article, the authors investigated the 3D genome architecture across normal B cell differentiation and in neoplastic cells from different subtypes of chronic lymphocytic leukemia and mantle cell lymphoma patients.

TL;DR: It is indicated that 3D genome interactions are extensively modulated during normal B cell differentiation and that the genome of B cell neoplasias acquires a tumor-specific3D genome architecture.

TL;DR: Examining plasma cells from MM using a multi-epigenomics approach demonstrated that when compared to normal B cells, malignant plasma cells showed an extensive activation of regulatory elements, in part affecting coregulated adjacent genes.

TL;DR: TADpole is introduced, a computational tool designed to identify and analyze the entire hierarchy of TADs in intra-chromosomal interaction matrices that combines principal component analysis and constrained hierarchical clustering to provide a set of significant hierarchical chromatin levels in a genomic region of interest.

TL;DR: In this paper, the authors proposed that colocalization of triplex hotspots targeted by lncRNAs could contribute to large-scale chromosome compartmentalization cooperating, rather than competing, with architectural transcription factors such as CTCF.