Irene Farabella

TL;DR: Focusing on chromosomal regions that contribute to compartments, it is discovered that distinct structures that, in spite of considerable variability, can predict whether such regions correspond to active or inactive compartments.

TL;DR: Human islet 3D chromatin architecture provides a framework for interpretation of T2D genome-wide association study (GWAS) signals and identifies more than 1,300 three-dimensional regulatory hubs, linking diabetes-associated enhancers to their target genes.

TL;DR: It is shown that suilysin assembly is a noncooperative process that is terminated before the protein inserts into the membrane, and the resulting ring-shaped pores and kinetically trapped arc-shaped assemblies are all seen to perforate the membrane.

TL;DR: Rec recessive loss-of-function SLC12A5 mutations in patients with a severe infantile-onset pharmacoresistant epilepsy syndrome, epilepsy of infancy with migrating focal seizures (EIMFS), contribute to loss of KCC2 activity, thereby impairing normal synaptic inhibition and promoting neuronal excitability in this early-ONSet epileptic encephalopathy.

TL;DR: The results suggest that MACPF conformational change is triggered through disruption of the interface between a conserved helix-turn-helix motif and the top of TMH2, suggesting why this region is targeted by endogenous inhibitors of MACPF function.