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Edurne San José-Enériz
Researcher at University of Navarra
Publications - 50
Citations - 2727
Edurne San José-Enériz is an academic researcher from University of Navarra. The author has contributed to research in topics: Epigenetics & DNA methylation. The author has an hindex of 28, co-authored 45 publications receiving 2308 citations. Previous affiliations of Edurne San José-Enériz include Carlos III Health Institute & Chartered Institute of Management Accountants.
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Journal ArticleDOI
Epigenetic silencing of the tumor suppressor microRNA Hsa-miR-124a regulates CDK6 expression and confers a poor prognosis in acute lymphoblastic leukemia
Xabier Agirre,Amaia Vilas-Zornoza,Antonio Jiménez-Velasco,José I. Martín-Subero,Lucia Cordeu,Leire Garate,Edurne San José-Enériz,Gloria Abizanda,Paula Rodriguez-Otero,Puri Fortes,José Rifón,Eva Bandrés,María José Calasanz,Vanesa Martín,Anabel Heiniger,Antoni Torres,Reiner Siebert,Jose Roman-Gomez,Felipe Prosper +18 more
TL;DR: The methylation and chromatin status of the miR-124a loci in ALL provided the grounds for new therapeutic strategies in ALL either targeting the epigenetic regulation of microRNAs and/or directly targeting the CDK6-Rb pathway.
Journal ArticleDOI
Down-regulation of hsa-miR-10a in chronic myeloid leukemia CD34+ cells increases USF2-mediated cell growth.
Xabier Agirre,Antonio Jiménez-Velasco,Edurne San José-Enériz,Leire Garate,Eva Bandrés,Lucia Cordeu,Oscar Aparicio,Borja Saez,German Navarro,Amaia Vilas-Zornoza,Ignacio Pérez-Roger,Jesús García-Foncillas,Antoni Torres,Anabel Heiniger,María José Calasanz,Puri Fortes,Jose Roman-Gomez,Felipe Prosper +17 more
TL;DR: The results indicate that down-regulation of hsa-miR-10a may increase USF2 and contribute to the increase in cell proliferation of CML implicating a miRNA in the abnormal behavior of C ML.
Journal ArticleDOI
Epigenetic regulation of Wnt-signaling pathway in acute lymphoblastic leukemia
Jose Roman-Gomez,Lucia Cordeu,Xabier Agirre,Antonio Jiménez-Velasco,Edurne San José-Enériz,Leire Garate,María José Calasanz,Anabel Heiniger,Antoni Torres,Felipe Prosper +9 more
TL;DR: A role of abnormal Wnt signaling in ALL is indicated and a group of patients with a significantly worse prognosis is established that is associated with decreased 10-year disease-free survival and overall survival.
Journal ArticleDOI
Epigenetic Regulation of MicroRNAs in Acute Lymphoblastic Leukemia
Jose Roman-Gomez,Xabier Agirre,Antonio Jiménez-Velasco,Victor Arqueros,Amaia Vilas-Zornoza,Paula Rodriguez-Otero,Iñaki Martin-Subero,Leire Garate,Lucia Cordeu,Edurne San José-Enériz,Vanesa Martin,Juan A. Castillejo,Eva Bandrés,María José Calasanz,Reiner Siebert,Anabel Heiniger,Antoni Torres,Felipe Prosper +17 more
TL;DR: Aberrant miRNA methylation is a common phenomenon in ALL that affects the clinical outcome of these patients andMultivariate analysis demonstrated that methylation profile was an independent prognostic factor for predicting DFS and OS.
Journal ArticleDOI
Characterization of the paracrine effects of human skeletal myoblasts transplanted in infarcted myocardium.
Maitane Pérez-Ilzarbe,Onnik Agbulut,Beatriz Pelacho,Cristina Ciorba,Edurne San José-Enériz,Michel Desnos,Albert Hagège,Pablo Aranda,Enrique J. Andreu,Philippe Menasché,Felipe Prosper +10 more
TL;DR: The discrepancy between the functional improvements yielded experimentally by skeletal myoblasts transplanted in infarcted myocardium and the paucity of their long‐term engraftment has raised the hypothesis of cell‐mediated paracrine mechanisms.