P
Paulette Mhawech-Fauceglia
Researcher at Roswell Park Cancer Institute
Publications - 86
Citations - 4520
Paulette Mhawech-Fauceglia is an academic researcher from Roswell Park Cancer Institute. The author has contributed to research in topics: Cancer & Ovarian cancer. The author has an hindex of 33, co-authored 82 publications receiving 4033 citations. Previous affiliations of Paulette Mhawech-Fauceglia include New Zealand Institute for Crop and Food Research & Geneva College.
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Journal ArticleDOI
Tumor-infiltrating NY-ESO-1–specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer
Junko Matsuzaki,Sacha Gnjatic,Paulette Mhawech-Fauceglia,Amy Beck,Austin Miller,Takemasa Tsuji,Cheryl Eppolito,Feng Qian,Shashikant Lele,Protul Shrikant,Lloyd J. Old,Kunle Odunsi +11 more
TL;DR: Dual blockade of LAG-3 and PD-1 during T-cell priming efficiently augmented proliferation and cytokine production by NY-ESO-1–specific CD8+ T cells, indicating that antitumor function of NY-eso-1-specific CD 8+ T Cells could potentially be improved by therapeutic targeting of these inhibitory receptors.
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Ovarian Cancer Spheroid Cells with Stem Cell-Like Properties Contribute to Tumor Generation, Metastasis and Chemotherapy Resistance through Hypoxia-Resistant Metabolism
Jianqun Liao,Feng Qian,Nana Tchabo,Paulette Mhawech-Fauceglia,Amy Beck,Zikun Qian,Xinhui Wang,Wendy J. Huss,Shashikant Lele,Carl Morrison,Kunle Odunsi +10 more
TL;DR: In insight into the relationship between tumor dissemination and metabolic attributes of human cancer stem cells, spheroid cells were found to be enriched for cells with cancer stem cell-like characteristics and contributed to tumor generation, progression and chemotherapy resistance.
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Prostate‐specific membrane antigen (PSMA) protein expression in normal and neoplastic tissues and its sensitivity and specificity in prostate adenocarcinoma: an immunohistochemical study using mutiple tumour tissue microarray technique
Paulette Mhawech-Fauceglia,Shaozeng Zhang,L. Terracciano,Guido Sauter,A. Chadhuri,François Herrmann,Remedios B. Penetrante +6 more
TL;DR: The objective is to determine prostate‐specific membrane antigen (PSMA) expression in normal tissues and in 3161 benign and malignant tumours and subsequently to define its sensitivity and specificity in prostatic adenocarcinoma (PaC).
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Vaccination with an NY-ESO-1 peptide of HLA class I/II specificities induces integrated humoral and T cell responses in ovarian cancer
Kunle Odunsi,Feng Qian,Junko Matsuzaki,Paulette Mhawech-Fauceglia,Chris Andrews,Eric W. Hoffman,Linda Pan,Gerd Ritter,Jeannine A. Villella,Bridget Thomas,Kerry J. Rodabaugh,Shashikant Lele,Protul Shrikant,Lloyd J. Old,Sacha Gnjatic +14 more
TL;DR: Results confirm the paradigm that the provision of cognate CD4+ T cell help is important for cancer vaccine design and provides the rationale for a phase II study design using ESO157–170 epitope or the full-length NY-ESO-1 protein for immunotherapy in patients with EOC.
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Efficacy of vaccination with recombinant vaccinia and fowlpox vectors expressing NY-ESO-1 antigen in ovarian cancer and melanoma patients
Kunle Odunsi,Junko Matsuzaki,Julia Karbach,Antje Neumann,Paulette Mhawech-Fauceglia,Austin Miller,Amy Beck,Carl Morrison,Gerd Ritter,Heidi Godoy,Shashikant Lele,Nefertiti C. duPont,Robert Edwards,Protul Shrikant,Lloyd J. Old,Sacha Gnjatic,Elke Jäger +16 more
TL;DR: Preliminary evidence of clinically meaningful benefit for diversified prime and boost recombinant pox-viral-based vaccines in melanoma and ovarian cancer is provided and support further evaluation of this approach in these patient populations are supported.