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Pauliina Korhonen
Researcher at University of Eastern Finland
Publications - 12
Citations - 512
Pauliina Korhonen is an academic researcher from University of Eastern Finland. The author has contributed to research in topics: Transcription factor & Downregulation and upregulation. The author has an hindex of 10, co-authored 12 publications receiving 497 citations.
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Age-related changes in the regulation of transcription factor NF-κB in rat brain
TL;DR: A significant up-regulation in the constitutive, nucleus-located NF- κ B binding activity was observed in 30- month-old Wistar rats compared to young and 18-month-old rats, which may be related to the NF-κ B driven cellular response to adapt neurons against apoptotic pressure, as observed recently in several apoptotic conditions.
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Neuronal apoptosis induced by histone deacetylase inhibitors
TL;DR: Observations show that an excessive level of histone acetylation induces a stress response and an apoptotic cell death in neuronal cells.
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Down-Regulation of Transcription Factors AP-1, Sp-1, and NF-κB Precedes Myocyte Differentiation
TL;DR: The results show that the down-regulation of the proliferation-promoting transcription factors is a prerequisite to the initiation of myocyte differentiation.
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Regulation of PTEN expression in neuronal apoptosis
TL;DR: It seems that the changes in PTEN expression level and neuronal apoptosis are not related to each other in general but the expression of PTEN phosphatase seems to regulate certain apoptotic signals affecting phosphoinositide 3-kinase function.
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Down-Regulation of Ku Autoantigen, DNA-Dependent Protein Kinase, and Poly(ADP-ribose) Polymerase during Cellular Senescence
Antero Salminen,Merja Helenius,Tomi Lahtinen,Pauliina Korhonen,Tero Tapiola,Hilkka Soininen,Victor Solovyan,Victor Solovyan +7 more
TL;DR: The results show that replicative senescence and to some extent cellular quiescence down-regulate the recognition system of DNA damage involving Ku autoantigens, DNA-dependent protein kinase, and PARP and hence could enhance the accumulation ofDNA damage during aging.