P
Paulo L. Onuchic
Researcher at Scripps Research Institute
Publications - 10
Citations - 708
Paulo L. Onuchic is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: RNA & Gene. The author has an hindex of 4, co-authored 7 publications receiving 392 citations.
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Journal ArticleDOI
Reentrant Phase Transition Drives Dynamic Substructure Formation in Ribonucleoprotein Droplets
Priya R. Banerjee,Anthony N. Milin,Mahdi Muhammad Moosa,Mahdi Muhammad Moosa,Paulo L. Onuchic,Ashok A. Deniz +5 more
TL;DR: It is demonstrated that RNA, a primary component of RNP granules, can modulate the phase behavior of RNPs by controlling both droplet assembly and dissolution in vitro.
Journal ArticleDOI
Self-interaction of NPM1 modulates multiple mechanisms of liquid–liquid phase separation
Diana M. Mitrea,Jaclyn A Cika,Jaclyn A Cika,Jaclyn A Cika,Christopher B. Stanley,Amanda Nourse,Paulo L. Onuchic,Priya R. Banerjee,Priya R. Banerjee,Aaron H. Phillips,Cheon-Gil Park,Ashok A. Deniz,Richard W. Kriwacki,Richard W. Kriwacki +13 more
TL;DR: It is proposed that this newly discovered interplay between multiple LLPS mechanisms may influence the direction of vectorial pre-ribosomal particle assembly within, and exit from the nucleolus as part of the ribosome biogenesis process.
Journal ArticleDOI
Frontispiece: Reentrant Phase Transition Drives Dynamic Substructure Formation in Ribonucleoprotein Droplets
Priya R. Banerjee,Anthony N. Milin,Mahdi Muhammad Moosa,Mahdi Muhammad Moosa,Paulo L. Onuchic,Ashok A. Deniz +5 more
Journal ArticleDOI
Single-molecule fluorescence studies of intrinsically disordered proteins and liquid phase separation.
TL;DR: The conceptual motivations for development and application of single-molecule fluorescence methods for IDP studies are covered, and a few key examples of systems and biophysical problems that have been addressed are addressed, and thoughts for emerging and future directions are concluded.
Posted ContentDOI
Divalent cations can control a switch-like behavior in heterotypic and homotypic RNA coacervates
TL;DR: It is predicted and observed that variations in signaling cations exert interaction-dependent effects on RNA LLPS, and this work may provide a generic mechanism for modulating the biochemical environment of RNA coacervates in a cellular context.