P
Pavel Krejci
Researcher at Masaryk University
Publications - 112
Citations - 3521
Pavel Krejci is an academic researcher from Masaryk University. The author has contributed to research in topics: Fibroblast growth factor & Wnt signaling pathway. The author has an hindex of 34, co-authored 98 publications receiving 3056 citations. Previous affiliations of Pavel Krejci include European Institute & University of California, Los Angeles.
Papers
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Journal ArticleDOI
Sixteen years and counting: the current understanding of fibroblast growth factor receptor 3 (FGFR3) signaling in skeletal dysplasias.
TL;DR: The challenging journey to unravel the mechanisms of FGFR3 function in skeletal dysplasias, the extraordinary cellular manifestations ofFGFR3 signaling in chondrocytes, and finally, the progress toward therapy for ACH and cancer are described.
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Interaction of fibroblast growth factor and C-natriuretic peptide signaling in regulation of chondrocyte proliferation and extracellular matrix homeostasis
Pavel Krejci,Bernard Masri,Vincent Fontaine,Pertchoui B. Mekikian,MaryAnn Weis,Hervé Prats,William R. Wilcox,William R. Wilcox +7 more
TL;DR: CNP utilizes both direct and indirect ways to counteract the effects of FGF signaling in a chondrocyte environment to demonstrate that CNP blocks the Erk pathway at the level of Raf-1.
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Receptor Tyrosine Kinases Activate Canonical WNT/β-Catenin Signaling via MAP Kinase/LRP6 Pathway and Direct β-Catenin Phosphorylation
Pavel Krejci,Pavel Krejci,Anie Aklian,Marketa Kaucka,Eva Sevcikova,Jirina Prochazkova,Jan Masek,Pavol Mikolka,Tereza Pospisilova,Tereza Spoustova,MaryAnn Weis,William A. Paznekas,Joshua Wolf,J. Silvio Gutkind,William R. Wilcox,William R. Wilcox,Alois Kozubík,Ethylin Wang Jabs,Vitezslav Bryja,Lisa Salazar,Iva Vesela,Lukas Balek +21 more
TL;DR: It is concluded that signaling via ERK/LRP6 pathway and direct β-catenin phosphorylation at Tyr142 represent two mechanisms used by various receptor tyrosine kinase systems to activate canonical WNT signaling.
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Exome Sequencing Identifies PDE4D Mutations in Acrodysostosis
Hane Lee,John M. Graham,John M. Graham,David L. Rimoin,Ralph S. Lachman,Ralph S. Lachman,Pavel Krejci,Pavel Krejci,Stuart W. Tompson,Stanley F. Nelson,Deborah Krakow,Daniel H. Cohn +11 more
TL;DR: It is demonstrated that acrodysostosis is genetically heterogeneous and underscore the exquisite sensitivity of many tissues to alterations in cAMP homeostasis.
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The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival
Anna Scuto,Pavel Krejci,Pavel Krejci,Leslie Popplewell,Jun Wu,Y. Wang,Maciej Kujawski,Claudia M. Kowolik,Hong Xin,L. Chen,Leo Kretzner,Hua Yu,William R. Wilcox,William R. Wilcox,Yun Yen,S.J. Forman,Richard Jove +16 more
TL;DR: AZD1480 blocks proliferation, survival, FGFR3 and JAK/STAT3 signaling in myeloma cells cultured alone or cocultured with BM stromal cells, and in vivo, and represents a potential new therapeutic agent for patients with MM.