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Pawan Sharma

Researcher at International Centre for Genetic Engineering and Biotechnology

Publications -  64
Citations -  885

Pawan Sharma is an academic researcher from International Centre for Genetic Engineering and Biotechnology. The author has contributed to research in topics: Antigen & Mycobacterium tuberculosis. The author has an hindex of 16, co-authored 64 publications receiving 820 citations.

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Journal Article

Effect of low intensity laser radiation on healing of open skin wounds in rats.

TL;DR: The study establishes the biostimulatory effects of low intensity laser radiation on healing of skin wounds and early epithelisation with increased fibroblastic reaction, leukocytic infiltration and neo vascularisation was seen in the laser irradiated wounds.
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Mycobacterium tuberculosis secretory proteins CFP-10, ESAT-6 and the CFP10:ESAT6 complex inhibit lipopolysaccharide-induced NF-κB transactivation by downregulation of reactive oxidative species (ROS) production

TL;DR: It is indicated that the secretory proteins CFP‐10, ESAT‐6 and the CFP10:ESAT6 complex of Mtb can inhibit LPS‐induced NF‐κB‐dependent gene expression via downregulation of ROS production.
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Mycobacterium tuberculosis 6-kDa Early Secreted Antigenic Target (ESAT-6) protein downregulates Lipopolysaccharide induced c-myc expression by modulating the Extracellular Signal Regulated Kinases 1/2

TL;DR: Results showed that RD-1-encoded secretory protein ESAT-6 is involved in modulation of the mitogen-activated protein (MAP) kinase-signaling pathway inside the macrophage, and this modulation appears to be achieved by limiting the ERK1/2 activation in the nucleus which ultimately affects the Macrophage gene expression.
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Comparative proteomic analysis of sequential isolates of Mycobacterium tuberculosis from a patient with pulmonary tuberculosis turning from drug sensitive to multidrug resistant.

TL;DR: This preliminary proteomic study provides an insight about the proteins that are upregulated during drug resistance development and could prove useful as immunodiagnostic and possibly drug resistant markers in future.
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Hypervalent Iodine Oxidative Rearrangement of Anthranilamides, Salicylamides and Some β-Substituted Amides: A New and Convenient Synthesis of 2-Benzimidazolones, 2-Benzoxazolones and Related Compounds

TL;DR: In this article, a new and convenient synthesis of 2-benzimidazolones, 2benzoxazolone and related compounds was proposed via initial Hofmann-type rearrangement followed by intramolecular cyclization of intermediate isocyanate.