P
Paweł Mierzejewski
Researcher at Medical University of Warsaw
Publications - 84
Citations - 1284
Paweł Mierzejewski is an academic researcher from Medical University of Warsaw. The author has contributed to research in topics: Antipsychotic & Medicine. The author has an hindex of 19, co-authored 74 publications receiving 1089 citations.
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Journal ArticleDOI
Time-dependent changes in alcohol-seeking behaviour during abstinence.
Przemyslaw Bienkowski,Artur Rogowski,Agnieszka Korkosz,Paweł Mierzejewski,Katarzyna Radwanska,Leszek Kaczmarek,Anna Bogucka-Bonikowska,Wojciech Kostowski +7 more
TL;DR: Alcohol-seeking behaviour may become more intense after long-term imposed abstinence and alcohol self-administration, extinction behaviour, and reinstatement of alcohol- seeking behaviour may be regulated by separate neural mechanisms.
Journal ArticleDOI
GABAB receptors as a therapeutic strategy in substance use disorders: Focus on positive allosteric modulators
Małgorzata Filip,Małgorzata Frankowska,Anna Sadakierska-Chudy,Agata Suder,Lukasz Szumiec,Paweł Mierzejewski,Przemyslaw Bienkowski,Edmund Przegaliński,John F. Cryan +8 more
TL;DR: A wealth of data now supports the benefits of GABAB receptor PAMs and clinical validation is now warranted, given that anxiolytic effects are reported with such ligands they may also benefit in mitigating the withdrawal from drugs of abuse.
Journal ArticleDOI
Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT6 receptor antagonists. Design, synthesis and biological evaluation.
Anna Więckowska,Marcin Kołaczkowski,Adam Bucki,Justyna Godyń,Monika Marcinkowska,Krzysztof Więckowski,Paula Zaręba,Agata Siwek,Grzegorz Kazek,Monika Głuch-Lutwin,Paweł Mierzejewski,Przemyslaw Bienkowski,Halina Sienkiewicz-Jarosz,Damijan Knez,Tomasz Wichur,Stanislav Gobec,Barbara Malawska +16 more
TL;DR: A novel class of multifunctional ligands with compound 12 as the best derivative in a series represents an excellent starting point for the further development of an effective treatment for AD.
Journal ArticleDOI
Novel arylsulfonamide derivatives with 5‑HT6/5-HT7 receptor antagonism targeting behavioral and psychological symptoms of dementia
Marcin Kołaczkowski,Monika Marcinkowska,Adam Bucki,Maciej Pawłowski,Katarzyna Mitka,Jolanta Jaśkowska,Piotr A. Kowalski,Grzegorz Kazek,Agata Siwek,Anna Wasik,Anna Wesołowska,Paweł Mierzejewski,Przemyslaw Bienkowski +12 more
TL;DR: Novel multifunctional arylsulfonamide derivatives that potently antagonize 5-HT(6/7/2A) and D2 receptors, without interacting with M1 receptors and hERG channels are obtained to target behavioral and psychological symptoms of dementia.
Journal Article
The effects of fatty acid amide hydrolase inhibitors on maintenance of cocaine and food self-administration and on reinstatement of cocaine-seeking and food-taking behavior in rats.
Przemysław Adamczyk,Andrew C. McCreary,Edmund Przegaliński,Paweł Mierzejewski,Przemyslaw Bienkowski,Małgorzata Filip +5 more
TL;DR: The results indicate that FAAH inhibitors could be potent modulators of motivational and conditioned aspects of goal-directed behaviors with less prominent effects on consumatory behaviors.