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Pawel Nowialis
Researcher at University of Florida
Publications - 7
Citations - 51
Pawel Nowialis is an academic researcher from University of Florida. The author has contributed to research in topics: DNA methylation & Methyltransferase. The author has an hindex of 3, co-authored 7 publications receiving 25 citations.
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Journal ArticleDOI
Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions
Pawel Nowialis,Katarina Lopusna,Jana Opavska,Staci L. Haney,Ajay Abraham,Peike Sheng,Alberto Riva,Amarnath Natarajan,Olga A. Guryanova,Melanie A. Simpson,Ryan A. Hlady,Mingyi Xie,Rene Opavsky +12 more
TL;DR: It is shown that catalytically inactive Dnmt3b rescues a majority of methylation and expression changes in the absence of DnMT3b during mouse embryonic development and is linked to a control of major developmental pathways, including Wnt and hedgehog signaling.
Journal ArticleDOI
Dnmt3b catalytic activity is critical for its tumour suppressor function in lymphomagenesis and is associated with c-Met oncogenic signalling.
TL;DR: In this paper, the authors used a mouse model expressing catalytically inactive Dnmt3b (Dnmt-3bCI) to study the role of Dnm3b's catalytic activity in development and cancer.
Journal ArticleDOI
A non-canonical microRNA derived from the snaR-A non-coding RNA targets a metastasis inhibitor
Daniel Stribling,Yi Lei,Casey M. Guardia,Lu Li,Christopher J. Fields,Pawel Nowialis,Rene Opavsky,Rolf Renne,Mingyi Xie +8 more
TL;DR: In this paper, the Target-Oriented miRNA Discovery (TOMiD) method was developed to identify Drosha-independent miRNAs from Argonaute crosslinking and sequencing of hybrid datasets.
Journal ArticleDOI
Decreases in different Dnmt3b activities drive distinct development of hematologic malignancies in mice
Katarina Lopusna,Pawel Nowialis,Jana Opavska,Ajay Abraham,Alberto Riva,Staci L. Haney,Rene Opavsky +6 more
TL;DR: In this article, the authors showed that Dnmt3b+/− mice developed T-cell lymphomas, chronic lymphocytic leukemia, and myeloproliferation over 18 months.
Posted ContentDOI
DNMT3A harboring leukemia-associated mutations directs sensitivity to DNA damage at replication forks
Kartika Venugopal,Pawel Nowialis,Yang Feng,Daniil Shabashvili,Cassandra M. Berntsen,Kathryn I. Krajcik,C. Taragjini,Zachary Zaroogian,H. L. Casellas-Roman,Luisa M Posada,Chamara Gunaratne,Jennifer W Li,Daphné Dupéré-Richer,Richard L. Bennett,Richard L. Bennett,Santhi Pondugula,Alberto Riva,Alberto Riva,Christopher R. Cogle,Christopher R. Cogle,Rene Opavsky,Rene Opavsky,Brian K. Law,Brian K. Law,Stefan Kubicek,Philipp B. Staber,Jonathan D. Licht,Jonathan D. Licht,Jonathan E. Bird,Olga A. Guryanova,Olga A. Guryanova +30 more
TL;DR: In this article, pharmacologically-induced replication fork stalling creates a therapeutic vulnerability in cells with DNMT3A(R882) mutations, which is associated with resistance to standard chemotherapy, disease relapse, and poor prognosis.