Yang Feng

TL;DR: In this article, the activation of HOXBLINC, a HOXB locus-associated long non-coding RNA (lncRNA), is shown to be a critical downstream mediator of NPM1c+-associated leukemic transcription program and leukemogenesis.

TL;DR: Recent advances in understanding of the biochemical and structural consequences of DNMT3A mutations on DNA methylation catalysis and binding interactions are discussed and their effects on epigenetic patterns and gene expression changes implicated in the pathogenesis of hematologic malignancies are summarized.

TL;DR: This review will focus on the research progress of T-cell exhaustion in several IMIDs and its potential application for diagnosis and treatment in IMIDs.

TL;DR: Venugopal et al. as discussed by the authors discussed PARP inhibition as a rational strategy to increase cytarabine efficacy in cells without DNMT3A mutations, while considering the implications of PARP inhibitor resistance for promoting clonal hematopoiesis.

TL;DR: In this article, pharmacologically-induced replication fork stalling creates a therapeutic vulnerability in cells with DNMT3A(R882) mutations, which is associated with resistance to standard chemotherapy, disease relapse, and poor prognosis.