Payal Ray

TL;DR: Comparing wild-type and an ALS-associated mutant TDP-43 in vitro and in vivo provides evidence for biochemical similarities between TPD-43 and prion proteins, raising the possibility that T DP-43 derivatives may cause spreading of the disease phenotype among neighboring neurons.

TL;DR: Transgenic flies expressing hTDP-43 recapitulate important neuropathological and clinical features of human TDP- 43 proteinopathy, providing a powerful animal model for this group of devastating diseases.

TL;DR: This work has uncovered a player in casp-2 alternativeSplicing regulation and revealed a link between the alternative splicing regulator and the candidate tumor suppressor gene, suggesting that splicing control of cell death genes may be an important aspect in tumorigenesis.

TL;DR: Activity of PGRN in mouse cortical and hippocampal neurons and in human neuroblastoma SH-SY5Y cells is examined, revealing an important role of P GRN in neurite outgrowth and involvement of GSK-3β in mediating PGRn activity.

TL;DR: This study reports the first RNA helicase interacting with a stem-loop structure at the splice site and regulating alternative splicing in a helicase-dependent manner and uncovers a previously unknown function of p68 in regulating tau exon 10 splicing.